International Polyamines Foundation ETS Official Website
Polyamines Papers
2024
Identification and enzymatic properties of arginine decarboxylase from Aspergillus oryzae. Yui Murakami, Soichiro Ikuta, Wakao Fukuda, Naoki Akasaka, Jun-ichi Maruyama, Shuichi Shinma, Eiichiro Fukusaki, Shinsuke Fujiwara (2024). Appl Environ Microbiol. 10.1128/aem.00294-24
Prenatal nicotine exposure leads to epigenetic alterations in peripheral nervous system signaling genes in the testis of the rat. Ouzna Dali, Jose Antonio Muriel-Muriel, Ana Vargas-Baco, Sergei Tevosian, Jasenka Zubcevic, Fatima Smagulova, Linda F. Hayward (2024). Epigenetics & Chromatin. 10.1186/s13072-024-00539-5
Polyamine Pathway Inhibitor DENSPM Suppresses Lipid Metabolism in Pheochromocytoma Cell Line. Hans K. Ghayee, Kaylie A. Costa, Yiling Xu, Heather M. Hatch, Mateo Rodriguez, Shelby C. Straight, Marian Bustamante, Fahong Yu, Fatima Smagulova, John A. Bowden, Sergei G. Tevosian (2024). IJMS. 10.3390/ijms251810029
Spermine oxidase promotes Helicobacter pylori-mediated gastric carcinogenesis through acrolein production. Kara M. McNamara, Johanna C. Sierra, Yvonne L. Latour, Caroline V. Hawkins, Mohammad Asim, Kamery J. Williams, Daniel P. Barry, Margaret M. Allaman, Irene Zagol-Ikapitte, Paula B. Luis, Claus Schneider, Alberto G. Delgado, M. Blanca Piazuelo, Regina N. Tyree, Kate S. Carson, Yash A. Choksi, Lori A. Coburn, Alain P. Gobert, Keith T. Wilson (2024). Oncogene. 10.1038/s41388-024-03218-7
The Development of LAT1 Efflux Agonists as Mechanistic Probes of Cellular Amino Acid Stress. Vandana Sekhar, Houssine Ikhlef, Alexandra Bunea, Viet S. Nguyen, Johan Joo, Mukund P. Tantak, Holly Moots, Otto Phanstiel (2024). Biomolecules. 10.3390/biom14030326
Impact of Difluoromethylornithine and AMXT 1501 on Gene Expression and Capsule Regulation in Streptococcus pneumoniae. Moses B. Ayoola, Leslie A. Shack, Otto Phanstiel, Bindu Nanduri (2024). Biomolecules. 10.3390/biom14020178
2023
Spermine Oxidase–Substrate Electrostatic Interactions: The Modulation of Enzyme Function by Neighboring Colloidal ɣ-Fe2O3. Graziano Rilievo, Massimiliano Magro, Federica Tonolo, Alessandro Cecconello, Lavinia Rutigliano, Aura Cencini, Simone Molinari, Maria Luisa Di Paolo, Cristian Fiorucci, Marianna Nicoletta Rossi, Manuela Cervelli, Fabio Vianello (2023). Biomolecules. 10.3390/biom13121800
Growth-promoting and low-salt adaptation responses boosted by spermidine in Strombidium parasulcatum, a marine bacteriovorous ciliate potentially applied to live feeds for marine larviculture. Hung-Yun Lin, Bo-Ying Su, Nodali Ndraha, Sheng-Fang Tsai, Kuo-Ping Chiang, Hsin-Yun Liu, Yong-Ting Kang, Wei-Yu Yeh, Che-Chia Tsao, Yi-Min Chen, Hsin-I Hsiao, Han-Jia Lin (2023). Aquaculture. 10.1016/j.aquaculture.2023.739616
The Role of Spermidine and Its Key Metabolites in Important, Pathogenic Human Viruses and in Parasitic Infections Caused by Plasmodium falciparum and Trypanosoma brucei. Annette Kaiser (2023). Biomolecules. 10.3390/biom13050803
An Undefined Interaction between Polyamines and Heat Shock Proteins Leads to Cellular Protection in Plasmodium falciparum and Proliferating Cells in Various Organisms. Xolani H. Makhoba, Rino Ragno, Annette Kaiser, Enzo Agostinelli (2023). Molecules. 10.3390/molecules28041686
Difluoromethylornithine rebalances aberrant polyamine ratios in Snyder–Robinson syndrome. Tracy Murray Stewart, Jackson R Foley, Cassandra E Holbert, Maxim Khomutov, Noushin Rastkari, Xianzun Tao, Alex R Khomutov, R Grace Zhai, Robert A Casero (2023). EMBO Mol Med. 10.15252/emmm.202317833
C-Methylated Spermidine Derivatives: Convenient Syntheses and Antizyme-Related Effects. Maxim A. Khomutov, Arthur I. Salikhov, Vladimir A. Mitkevich, Vera L. Tunitskaya, Olga A. Smirnova, Sergey P. Korolev, Alexander O. Chizhov, Marina B. Gottikh, Sergey N. Kochetkov, Alex R. Khomutov (2023). Biomolecules. 10.3390/biom13060916
Inhibition of nicotinic acetylcholine receptors by oligoarginine peptides and polyamine-related compounds. Lucy O. Ojomoko, Elena V. Kryukova, Natalya S. Egorova, Arthur I. Salikhov, Lyubov A. Epifanova, Daria A. Denisova, Alex R. Khomutov, Dmitry A. Sukhov, Alexander A. Vassilevski, Maxim A. Khomutov, Victor I. Tsetlin, Irina V. Shelukhina (2023). Front. Pharmacol.. 10.3389/fphar.2023.1327603
Rebalancing polyamine levels to treat Snyder–Robinson syndrome. Susan K Gilmour (2023). EMBO Mol Med. 10.15252/emmm.202318506
Polyamines as Universal Bioregulators across Kingdoms and Their role in Cellular Longevity and Death. Ewelina Stolarska, Ewelina Paluch-Lubawa, Magda Grabsztunowicz, Umesh Kumar Tanwar, Magdalena Arasimowicz-Jelonek, Otto Phanstiel, Autar K. Mattoo, Ewa Sobieszczuk-Nowicka (2023). Critical Reviews in Plant Sciences. 10.1080/07352689.2023.2247886
Genetic portrait of polyamine transporters in barley: insights in the regulation of leaf senescence. Ewelina Stolarska, Umesh Kumar Tanwar, Yufeng Guan, Magda Grabsztunowicz, Magdalena Arasimowicz-Jelonek, Otto Phanstiel, Ewa Sobieszczuk-Nowicka (2023). Front. Plant Sci.. 10.3389/fpls.2023.1194737
Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation. Sonia Coni, Rosa Bordone, Devon Michael Ivy, Zuleyha Nihan Yurtsever, Laura Di Magno, Rodrigo D’Amico, Bianca Cesaro, Alessandro Fatica, Francesca Belardinilli, Francesca Bufalieri, Marella Maroder, Enrico De Smaele, Lucia Di Marcotullio, Giuseppe Giannini, Enzo Agostinelli, Gianluca Canettieri (2023). Cancer Letters. 10.1016/j.canlet.2023.216120
Editorial: Polyamines and longevity – role of polyamine in plant survival. Luigi Parrotta, Ewa Sobieszczuk-Nowicka, Giampiero Cai (2023). Front. Plant Sci.. 10.3389/fpls.2023.1232386
2022
Acidic Shift of Optimum pH of Bovine Serum Amine Oxidase upon Immobilization onto Nanostructured Ferric Tannates. Graziano Rilievo, Alessandro Cecconello, Simone Molinari, Andrea Venerando, Lavinia Rutigliano, Gayathri T. Govardhan, Dinusha H. Kariyawasam, Ruth J. Arusei, Lucio Zennaro, Maria L. Di Paolo, Enzo Agostinelli, Fabio Vianello, Massimiliano Magro (2022). IJMS. 10.3390/ijms232012172
Substrate Specificity of an Aminopropyltransferase and the Biosynthesis Pathway of Polyamines in the Hyperthermophilic Crenarchaeon Pyrobaculum calidifontis. Wakao Fukuda, Mamoru Osaki, Yusuke Yasuda, Ryota Hidese, Tsunehiko Higuchi, Naoki Umezawa, Shinsuke Fujiwara, Eiichi Mizohata (2022). Catalysts. 10.3390/catal12050567
Ornithine Decarboxylase in Gastric Epithelial Cells Promotes the Immunopathogenesis of Helicobacter pylori Infection. Yvonne L. Latour, Johanna C. Sierra, Kara M. McNamara, Thaddeus M. Smith, Paula B. Luis, Claus Schneider, Alberto G. Delgado, Daniel P. Barry, Margaret M. Allaman, M. Wade Calcutt, Kevin L. Schey, M. Blanca Piazuelo, Alain P. Gobert, Keith T. Wilson (2022).10.4049/jimmunol.2100795
Protective Role of Spermidine in Colitis and Colon Carcinogenesis. Alain P. Gobert, Yvonne L. Latour, Mohammad Asim, Daniel P. Barry, Margaret M. Allaman, Jordan L. Finley, Thaddeus M. Smith, Kara M. McNamara, Kshipra Singh, Johanna C. Sierra, Alberto G. Delgado, Paula B. Luis, Claus Schneider, M. Kay Washington, M. Blanca Piazuelo, Shilin Zhao, Lori A. Coburn, Keith T. Wilson (2022). Gastroenterology. 10.1053/j.gastro.2021.11.005
Specific and sensitive GC–MS analysis of hypusine, Nε-(4-amino-2-hydroxybutyl)lysine, a biomarker of hypusinated eukaryotic initiation factor eIF5A, and its application to the bi-ethnic ASOS study. Svetlana Baskal, Annette Kaiser, Catharina Mels, Ruan Kruger, Dimitrios Tsikas (2022). Amino Acids. 10.1007/s00726-022-03142-8
Investigation of an Allosteric Deoxyhypusine Synthase Inhibitor in P. falciparum. Aiyada Aroonsri, Chayaphat Wongsombat, Philip Shaw, Siegrid Franke, Jude Przyborski, Annette Kaiser (2022). Molecules. 10.3390/molecules27082463
Hypusinated EIF5A as a feasible drug target for Advanced Medicinal Therapies in the treatment of pathogenic parasites and therapy-resistant tumors. Annette Kaiser, Enzo Agostinelli (2022). Amino Acids. 10.1007/s00726-021-03120-6
Synthesis of 2-Methylidene Spermidine and its N1-Acetylated Derivative. M. A. Khomutov, A. R. Khomutov (2022). Russ J Bioorg Chem. 10.1134/s1068162022060140
Role of Polyamine-Induced Dimerization of Antizyme in Its Cellular Functions. Mervi T. Hyvönen, Olga A. Smirnova, Vladimir A. Mitkevich, Vera L. Tunitskaya, Maxim Khomutov, Dmitry S. Karpov, Sergey P. Korolev, Merja R. Häkkinen, Marko Pietilä, Marina B. Gottikh, Jouko Vepsäläinen, Leena Alhonen, Alexander A. Makarov, Sergey N. Kochetkov, Heather M. Wallace, Tuomo A. Keinänen, Alex R. Khomutov (2022). IJMS. 10.3390/ijms23094614
Difluoromethylornithine (DFMO) Enhances the Cytotoxicity of PARP Inhibition in Ovarian Cancer Cells. Olivia El Naggar, Brenna Doyle, Kelsey Mariner, Susan K. Gilmour (2022). Medical Sciences. 10.3390/medsci10020028
Difluoromethylornithine (DFMO) and AMXT 1501 inhibit capsule biosynthesis in pneumococci. Moses B. Ayoola, Leslie A. Shack, Jung Hwa Lee, Juhyeon Lim, Hyungjin Eoh, Edwin Swiatlo, Otto Phanstiel, Bindu Nanduri (2022). Sci Rep. 10.1038/s41598-022-16007-7
ATP13A3 facilitates polyamine transport in human pancreatic cancer cells. Vandana Sekhar, Thomas Andl, Otto Phanstiel (2022). Sci Rep. 10.1038/s41598-022-07712-4
Elucidating the Role of Chmp1 Overexpression in the Transport of Polyamines in Drosophila melanogaster. Coryn L. Stump, Robert A. Casero, Otto Phanstiel, Justin R. DiAngelo, Shannon L. Nowotarski (2022). Medical Sciences. 10.3390/medsci10030045
Polyamine-Based Nanostructures Share Polyamine Transport Mechanisms with Native Polyamines and Their Analogues: Significance for Polyamine-Targeted Therapy. Cassandra E. Holbert, Jackson R. Foley, Ao Yu, Tracy Murray Stewart, Otto Phanstiel, David Oupicky, Robert A. Casero (2022). Medical Sciences. 10.3390/medsci10030044
Bovine Serum Amine Oxidase and Polyamine Analogues: Chemical Synthesis and Biological Evaluation Integrated with Molecular Docking and 3-D QSAR Studies. Rino Ragno, Anna Minarini, Eleonora Proia, Antonini Lorenzo, Andrea Milelli, Vincenzo Tumiatti, Marco Fiore, Pasquale Fino, Lavinia Rutigliano, Rossella Fioravanti, Tomoaki Tahara, Elena Pacella, Antonio Greco, Gianluca Canettieri, Maria Luisa Di Paolo, Enzo Agostinelli (2022). J. Chem. Inf. Model.. 10.1021/acs.jcim.2c00559
Anticancer Cytotoxic Activity of Bispidine Derivatives Associated with the Increasing Catabolism of Polyamines. Ekaterina V. Neborak, Altynay B. Kaldybayeva, Lylia Bey, Aigul Y. Malmakova, Anna S. Tveritinova, Abdullah Hilal, Valentina K. Yu, Maria V. Ploskonos, Marina V. Komarova, Enzo Agostinelli, Dmitry D. Zhdanov (2022). Molecules. 10.3390/molecules27123872
Plant homocysteine, a methionine precursor and plant’s hallmark of metabolic disorders. Ewa Sobieszczuk-Nowicka, Magdalena Arasimowicz-Jelonek, Umesh Kumar Tanwar, Jolanta Floryszak-Wieczorek (2022). Front. Plant Sci.. 10.3389/fpls.2022.1044944
Comparative genomic analysis of the aldehyde dehydrogenase gene superfamily in Arabidopsis thaliana – searching for the functional key to hypoxia tolerance. Yufeng Guan, Umesh Kumar Tanwar, Ewa Sobieszczuk-Nowicka, Jolanta Floryszak-Wieczorek, Magdalena Arasimowicz-Jelonek (2022). Front. Plant Sci.. 10.3389/fpls.2022.1000024
2021
The Polyamine Regulator AMD1 Upregulates Spermine Levels to Drive Epidermal Differentiation. Anisa B. Rahim, Hui Kheng Lim, Christina Yan Ru Tan, Li Jia, Vonny Ivon Leo, Takeshi Uemura, Jonathan Hardman-Smart, John E.A. Common, Thiam Chye Lim, Sophie Bellanger, Ralf Paus, Kazuei Igarashi, Henry Yang, Leah A. Vardy (2021). Journal of Investigative Dermatology. 10.1016/j.jid.2021.01.039
Ornithine decarboxylase (ODC1) gene variant (rs2302615) is associated with gastric cancer independently of Helicobacter pylori CagA serostatus. Anna K. Miller, Gloria Tavera, Ricardo L. Dominguez, M. Constanza Camargo, Tim Waterboer, Keith T. Wilson, Scott M. Williams, Douglas R. Morgan (2021). Oncogene. 10.1038/s41388-021-01981-5
The role of polyamines in gastric cancer. Kara M. McNamara, Alain P. Gobert, Keith T. Wilson (2021). Oncogene. 10.1038/s41388-021-01862-x
Toxic or Not Toxic, That Is the Carbon Quantum Dot’s Question: A Comprehensive Evaluation with Zebrafish Embryo, Eleutheroembryo, and Adult Models. Chih-Yu Chung, Yu-Ju Chen, Chia-Hui Kang, Hung-Yun Lin, Chih-Ching Huang, Pang-Hung Hsu, Han-Jia Lin (2021). Polymers. 10.3390/polym13101598
α-Difluoromethylornithine-Induced Cytostasis is Reversed by Exogenous Polyamines, Not by Thymidine Supplementation. Mervi T. Hyvönen, Maxim Khomutov, Jouko Vepsäläinen, Alex R. Khomutov, Tuomo A. Keinänen (2021). Biomolecules. 10.3390/biom11050707
DFMO Improves Survival and Increases Immune Cell Infiltration in Association with MYC Downregulation in the Pancreatic Tumor Microenvironment. Sai Preethi Nakkina, Sarah B. Gitto, Jordan M. Beardsley, Veethika Pandey, Michael W. Rohr, Jignesh G. Parikh, Otto Phanstiel, Deborah A. Altomare (2021). IJMS. 10.3390/ijms222413175
Development of a Redox-Sensitive Spermine Prodrug for the Potential Treatment of Snyder Robinson Syndrome. Mukund P. Tantak, Vandana Sekhar, Xianzun Tao, R. Grace Zhai, Otto Phanstiel (2021). J. Med. Chem.. 10.1021/acs.jmedchem.1c00419
Uptake of Biotinylated Spermine in Astrocytes: Effect of Cx43 siRNA, HIV-Tat Protein and Polyamine Transport Inhibitor on Polyamine Uptake. Christian J. Malpica-Nieves, Yomarie Rivera, David E. Rivera-Aponte, Otto Phanstiel, Rüdiger W. Veh, Misty J. Eaton, Serguei N. Skatchkov (2021). Biomolecules. 10.3390/biom11081187
Translational control of polyamine metabolism by CNBP is required for Drosophila locomotor function. Sonia Coni, Federica A Falconio, Marta Marzullo, Marzia Munafò, Benedetta Zuliani, Federica Mosti, Alessandro Fatica, Zaira Ianniello, Rosa Bordone, Alberto Macone, Enzo Agostinelli, Alessia Perna, Tanja Matkovic, Stephan Sigrist, Gabriella Silvestri, Gianluca Canettieri, Laura Ciapponi (2021).10.7554/elife.69269
Enzymatic Spermine Metabolites Induce Apoptosis Associated with Increase of p53, caspase-3 and miR-34a in Both Neuroblastoma Cells, SJNKP and the N-Myc-Amplified Form IMR5. Yuta Kanamori, Alessia Finotti, Laura Di Magno, Gianluca Canettieri, Tomoaki Tahara, Fabio Timeus, Antonio Greco, Paola Tirassa, Jessica Gasparello, Pasquale Fino, Carlo Di Liegro, Patrizia Proia, Gabriella Schiera, Italia Di Liegro, Roberto Gambari, Enzo Agostinelli (2021). Cells. 10.3390/cells10081950
2020
Nanotechnology-Based Strategies to Develop New Anticancer Therapies. Massimiliano Magro, Andrea Venerando, Alberto Macone, Gianluca Canettieri, Enzo Agostinelli, Fabio Vianello (2020). Biomolecules. 10.3390/biom10050735
The Polyamine Putrescine Promotes Human Epidermal Melanogenesis. Aishwarya Sridharan, Meng Shi, Vonny Ivon Leo, Nagavidya Subramaniam, Thiam Chye Lim, Takeshi Uemura, Kazuei Igarashi, Steven Thng Tien Guan, Nguan Soon Tan, Leah A. Vardy (2020). Journal of Investigative Dermatology. 10.1016/j.jid.2020.02.009
Spermine oxidase mediates Helicobacter pylori-induced gastric inflammation, DNA damage, and carcinogenic signaling. Johanna C. Sierra, M. Blanca Piazuelo, Paula B. Luis, Daniel P. Barry, Margaret M. Allaman, Mohammad Asim, Thomas A. Sebrell, Jordan L. Finley, Kristie L. Rose, Salisha Hill, Steven L. Holshouser, Robert A. Casero, John L. Cleveland, Patrick M. Woster, Kevin L. Schey, Diane Bimczok, Claus Schneider, Alain P. Gobert, Keith T. Wilson (2020). Oncogene. 10.1038/s41388-020-1304-6
Synthesis of (3R,10R)- and (3S,10S)-Diastereomers of 3,10-Dimethylspermine. M. A. Khomutov, M. T. Hyvönen, A. I. Salikhov, A. O. Chizhov, I. M. Ryzhov, S. N. Kochetkov, J. Vepsäläinen, T. A. Keinänen, A. R. Khomutov (2020). Russ J Bioorg Chem. 10.1134/s1068162020060126
Virion-Associated Polyamines Transmit with Bunyaviruses to Maintain Infectivity and Promote Entry. Vincent Mastrodomenico, Jeremy J. Esin, Shefah Qazi, Maxim A. Khomutov, Alexander V. Ivanov, Suchetana Mukhopadhyay, Bryan C. Mounce (2020). ACS Infect. Dis.. 10.1021/acsinfecdis.0c00402
(R,R)-1,12-Dimethylspermine can mitigate abnormal spermidine accumulation in Snyder–Robinson syndrome. Tracy Murray Stewart, Maxim Khomutov, Jackson R. Foley, Xin Guo, Cassandra E. Holbert, Tiffany T. Dunston, Charles E. Schwartz, Kathleen Gabrielson, Alexey Khomutov, Robert A. Casero (2020). Journal of Biological Chemistry. 10.1074/jbc.ra119.011572
Hydroxylamine Analogue of Agmatine: Magic Bullet for Arginine Decarboxylase. Mervi T. Hyvönen, Tuomo A. Keinänen, Gulgina K. Nuraeva, Dmitry V. Yanvarev, Maxim Khomutov, Elena N. Khurs, Sergey N. Kochetkov, Jouko Vepsäläinen, Alexander A. Zhgun, Alex R. Khomutov (2020). Biomolecules. 10.3390/biom10030406
Identification of a novel substrate-derived spermine oxidase inhibitor. T. T. Dunston, M. A. Khomutov, S. B. Gabelli, T. M. Stewart, J. R. Foley, S. N. Kochetkov, A. R. Khomutov, R. A. Casero Jr. (2020). Acta Naturae. 10.32607/actanaturae.10992
Polyamine Blocking Therapy Decreases Survival of Tumor-Infiltrating Immunosuppressive Myeloid Cells and Enhances the Antitumor Efficacy of PD-1 Blockade. Eric T. Alexander, Kelsey Mariner, Julia Donnelly, Otto Phanstiel, Susan K. Gilmour (2020).10.1158/1535-7163.mct-19-1116
Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation. Sonia Coni, Silvia Maria Serrao, Zuleyha Nihan Yurtsever, Laura Di Magno, Rosa Bordone, Camilla Bertani, Valerio Licursi, Zaira Ianniello, Paola Infante, Marta Moretti, Marialaura Petroni, Francesca Guerrieri, Alessandro Fatica, Alberto Macone, Enrico De Smaele, Lucia Di Marcotullio, Giuseppe Giannini, Marella Maroder, Enzo Agostinelli, Gianluca Canettieri (2020). Cell Death Dis. 10.1038/s41419-020-03174-6
Biochemical and pathophysiological properties of polyamines. Enzo Agostinelli (2020). Amino Acids. 10.1007/s00726-020-02821-8
2019
The therapeutic and nutraceutical potential of agmatine, and its enhanced production using Aspergillus oryzae. Naoki Akasaka, Shinsuke Fujiwara (2019). Amino Acids. 10.1007/s00726-019-02720-7
The C‐terminal flexible region of branched‐chain polyamine synthase facilitates substrate specificity and catalysis. Ryota Hidese, Masataka Toyoda, Ken‐ichi Yoshino, Wakao Fukuda, Gita Adhirani Wihardja, Seigo Kimura, Junso Fujita, Masaru Niitsu, Tairo Oshima, Tadayuki Imanaka, Eiichi Mizohata, Shinsuke Fujiwara (2019). The FEBS Journal. 10.1111/febs.14949
PGC1α Inhibits Polyamine Synthesis to Suppress Prostate Cancer Aggressiveness. Lisa Kaminski, Stéphanie Torrino, Maeva Dufies, Zied Djabari, Romain Haider, François-René Roustan, Emilie Jaune, Kathiane Laurent, Nicolas Nottet, Jean-François Michiels, Maeva Gesson, Stéphane Rocchi, Nathalie M. Mazure, Matthieu Durand, Jean-François Tanti, Damien Ambrosetti, Stephan Clavel, Issam Ben-Sahra, Frédéric Bost (2019).10.1158/0008-5472.can-18-2043
Involvement of the biogenic active amine agmatine in mitochondrial membrane permeabilization and release of pro-apoptotic factors. Pamela Martinis, Silvia Grancara, Yuta Kanamori, Aída Nelly García-Argáez, Elena Pacella, Lisa Dalla Via, Antonio Toninello, Enzo Agostinelli (2019). Amino Acids. 10.1007/s00726-019-02791-6
The role of polyamines in the regulation of macrophage polarization and function. Yvonne L. Latour, Alain P. Gobert, Keith T. Wilson (2019). Amino Acids. 10.1007/s00726-019-02719-0
Bacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway. Alain P. Gobert, Yvonne L. Latour, Mohammad Asim, Jordan L. Finley, Thomas G. Verriere, Daniel P. Barry, Ginger L. Milne, Paula B. Luis, Claus Schneider, Emilio S. Rivera, Kristie Lindsey-Rose, Kevin L. Schey, Alberto G. Delgado, Johanna C. Sierra, M. Blanca Piazuelo, Keith T. Wilson (2019). mBio. 10.1128/mbio.02174-19
α-Difluoromethylornithine reduces gastric carcinogenesis by causing mutations in Helicobacter pylori cagY. Johanna C. Sierra, Giovanni Suarez, M. Blanca Piazuelo, Paula B. Luis, Dara R. Baker, Judith Romero-Gallo, Daniel P. Barry, Claus Schneider, Douglas R. Morgan, Richard M. Peek, Alain P. Gobert, Keith T. Wilson (2019). Proc. Natl. Acad. Sci. U.S.A.. 10.1073/pnas.1814497116
Unforeseen Possibilities To Investigate the Regulation of Polyamine Metabolism Revealed by Novel C-Methylated Spermine Derivatives. Maxim Khomutov, Mervi T. Hyvönen, Alina Simonian, Andrey A. Formanovsky, Irina V. Mikhura, Alexander O. Chizhov, Sergey N. Kochetkov, Leena Alhonen, Jouko Vepsäläinen, Tuomo A. Keinänen, Alex R. Khomutov (2019). J. Med. Chem.. 10.1021/acs.jmedchem.9b01666
C-Methylated Analogs of Spermine and Spermidine: Synthesis and Biological Activity. M. A. Khomutov, I. V. Mikhura, S. N. Kochetkov, A. R. Khomutov (2019). Russ J Bioorg Chem. 10.1134/s1068162019060207
Synthesis of (R)- and (S)-isomers of 2-methylspermidine. Maxim A. Khomutov, Alexander O. Chizhov, Sergey N. Kochetkov, Alex R. Khomutov (2019). Mendeleev Communications. 10.1016/j.mencom.2019.11.025
Polyamine-stimulation of arsenic-transformed keratinocytes. Eric T Alexander, Kelsey Mariner, Yelizaveta Borodyanskaya, Allyson Minton, Susan K Gilmour (2019).10.1093/carcin/bgz115
Polyamines: The possible missing link between mental disorders and epilepsy (Review). Giulia Baroli, Jonathan Sanchez, Enzo Agostinelli, Paolo Mariottini, Manuela Cervelli (2019). Int J Mol Med. 10.3892/ijmm.2019.4401
Maize polyamine oxidase in the presence of spermine/spermidine induces the apoptosis of LoVo human colon adenocarcinoma cells. Shinji Ohkubo, Romina Mancinelli, Selenia Miglietta, Alessandra Cona, Riccardo Angelini, Gianluca Canettieri, Demetrios Spandidos, Eugenio Gaudio, Enzo Agostinelli (2019). Int J Oncol. 10.3892/ijo.2019.4780
Polyamine Metabolism as a Therapeutic Target in Hedgehog-Driven Basal Cell Carcinoma and Medulloblastoma. Sonia Coni, Laura Di Magno, Silvia Maria Serrao, Yuta Kanamori, Enzo Agostinelli, Gianluca Canettieri (2019). Cells. 10.3390/cells8020150
Link between spermine oxidase and apoptosis antagonizing transcription factor: A new pathway in neuroblastoma. Emiliano Fratini, Manuela Cervelli, Paolo Mariottini, Yuta Kanamori, Roberto Amendola, Enzo Agostinelli (2019). Int J Oncol. 10.3892/ijo.2019.4878
Exploring the activity of polyamine analogues on polyamine and spermine oxidase: methoctramine, a potent and selective inhibitor of polyamine oxidase. Maria Luisa Di Paolo, Manuela Cervelli, Paolo Mariottini, Alessia Leonetti, Fabio Polticelli, Michela Rosini, Andrea Milelli, Filippo Basagni, Rina Venerando, Enzo Agostinelli, Anna Minarini (2019). Journal of Enzyme Inhibition and Medicinal Chemistry. 10.1080/14756366.2019.1584620
Polyamines – A New Metabolic Switch: Crosstalk With Networks Involving Senescence, Crop Improvement, and Mammalian Cancer Therapy. Ewa Sobieszczuk-Nowicka, Ewelina Paluch-Lubawa, Autar K. Mattoo, Magdalena Arasimowicz-Jelonek, Per L. Gregersen, Andrzej Pacak (2019). Front. Plant Sci.. 10.3389/fpls.2019.00859
2018
Endogenous and food-derived polyamines: determination by electrochemical sensing. Davide Baratella, Emanuela Bonaiuto, Massimiliano Magro, Jessica de Almeida Roger, Yuta Kanamori, Giuseppina Pace Pereira Lima, Enzo Agostinelli, Fabio Vianello (2018). Amino Acids. 10.1007/s00726-018-2617-4
Agmatine Production by Aspergillus oryzae Is Elevated by Low pH during Solid-State Cultivation. Naoki Akasaka, Saori Kato, Saya Kato, Ryota Hidese, Yutaka Wagu, Hisao Sakoda, Shinsuke Fujiwara (2018). Appl Environ Microbiol. 10.1128/aem.00722-18
MINDY1 Is a Downstream Target of the Polyamines and Promotes Embryonic Stem Cell Self-Renewal. Christina James, Tian Yun Zhao, Anisa Rahim, Parul Saxena, Nazreen Abdul Muthalif, Takeshi Uemura, Norihiro Tsuneyoshi, Sheena Ong, Kazuei Igarashi, Chin Yan Lim, Norris Ray Dunn, Leah A. Vardy (2018).10.1002/stem.2830
Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses. Kshipra Singh, Lori A. Coburn, Mohammad Asim, Daniel P. Barry, Margaret M. Allaman, Chanjuan Shi, M. Kay Washington, Paula B. Luis, Claus Schneider, Alberto G. Delgado, M. Blanca Piazuelo, John L. Cleveland, Alain P. Gobert, Keith T. Wilson (2018).10.1158/0008-5472.can-18-0116
Distinct Immunomodulatory Effects of Spermine Oxidase in Colitis Induced by Epithelial Injury or Infection. Alain P. Gobert, Nicole T. Al-Greene, Kshipra Singh, Lori A. Coburn, Johanna C. Sierra, Thomas G. Verriere, Paula B. Luis, Claus Schneider, Mohammad Asim, Margaret M. Allaman, Daniel P. Barry, John L. Cleveland, Christina E. Destefano Shields, Robert A. Casero, M. Kay Washington, M. Blanca Piazuelo, Keith T. Wilson (2018). Front. Immunol.. 10.3389/fimmu.2018.01242
Polyamines in Microalgae: Something Borrowed, Something New. Hung-Yun Lin, Han-Jia Lin (2018). Marine Drugs. 10.3390/md17010001
Detection of urinary spermine by using silver-gold/silver chloride nanozymes. Po-Chih Kuo, Chia-Wen Lien, Ju-Yi Mao, Binesh Unnikrishnan, Huan-Tsung Chang, Han-Jia Lin, Chih-Ching Huang (2018). Analytica Chimica Acta. 10.1016/j.aca.2018.01.018
Acetylated derivatives of C-methylated analogues of spermidine: synthesis and interaction with N1-acetylpolyamine oxidase. Maxim A. Khomutov, Mervi T. Hyvönen, Alina R. Simonian, Janne Weisell, Jouko Vepsäläinen, Leena Alhonen, Sergey N. Kochetkov, Tuomo A. Keinänen, Alex R. Khomutov (2018). Mendeleev Communications. 10.1016/j.mencom.2018.09.008
A Novel Polyamine-Targeted Therapy for BRAF Mutant Melanoma Tumors. Molly Peters, Allyson Minton, Otto Phanstiel IV, Susan Gilmour (2018). Medical Sciences. 10.3390/medsci6010003
Plant organ senescence – regulation by manifold pathways. N. Wojciechowska, E. Sobieszczuk‐Nowicka, A. Bagniewska‐Zadworna (2018). Plant Biol J. 10.1111/plb.12672
2017
Effect of auxin and polyamines on protein contents and peroxidase activity during in vitro culture of taro. A.A. Francisco, P.R.R. Ramos, G.P.P. Lima, F. Vianello, S. Kanashiro, A.R. Tavares (2017). Acta Hortic.. 10.17660/actahortic.2017.1155.50
Identification of Branched-Chain Polyamines in Hyperthermophiles. Ryota Hidese, Wakao Fukuda, Masaru Niitsu, Shinsuke Fujiwara (2017).10.1007/978-1-4939-7398-9_8
Active site geometry of a novel aminopropyltransferase for biosynthesis of hyperthermophile‐specific branched‐chain polyamine. Ryota Hidese, Ka Man Tse, Seigo Kimura, Eiichi Mizohata, Junso Fujita, Yuhei Horai, Naoki Umezawa, Tsunehiko Higuchi, Masaru Niitsu, Tairo Oshima, Tadayuki Imanaka, Tsuyoshi Inoue, Shinsuke Fujiwara (2017). The FEBS Journal. 10.1111/febs.14262
Identification of a novel acetylated form of branched-chain polyamine from a hyperthermophilic archaeon Thermococcus kodakarensis. Ryota Hidese, Ki-Hwan Im, Masaki Kobayashi, Masaru Niitsu, Takemitsu Furuchi, Shinsuke Fujiwara (2017).10.1080/09168451.2017.1345616
Polyamines in brown rice vinegar function as potent attractants for the spotted wing drosophila. Naoki Akasaka, Haruka Higashikubo, Yuri Ishii, Hisao Sakoda, Shinsuke Fujiwara (2017). Journal of Bioscience and Bioengineering. 10.1016/j.jbiosc.2016.06.014
Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications. Dana M. Hardbower, Mohammad Asim, Paula B. Luis, Kshipra Singh, Daniel P. Barry, Chunying Yang, Meredith A. Steeves, John L. Cleveland, Claus Schneider, M. Blanca Piazuelo, Alain P. Gobert, Keith T. Wilson (2017). Proc. Natl. Acad. Sci. U.S.A.. 10.1073/pnas.1614958114
Super-Cationic Carbon Quantum Dots Synthesized from Spermidine as an Eye Drop Formulation for Topical Treatment of Bacterial Keratitis. Hong-Jyuan Jian, Ren-Siang Wu, Tzu-Yu Lin, Yu-Jia Li, Han-Jia Lin, Scott G. Harroun, Jui-Yang Lai, Chih-Ching Huang (2017). ACS Nano. 10.1021/acsnano.7b01023
Spermidine promotes Bacillus subtilis biofilm formation by activating expression of the matrix regulator slrR. Laura Hobley, Bin Li, Jennifer L. Wood, Sok Ho Kim, Jacinth Naidoo, Ana Sofia Ferreira, Maxim Khomutov, Alexey Khomutov, Nicola R. Stanley-Wall, Anthony J. Michael (2017). Journal of Biological Chemistry. 10.1074/jbc.m117.789644
Expression and distribution patterns of spermine, spermidine, and putrescine in rat hair follicle. Yutaro Yamamoto, Takamitsu Makino, Hideo Kudo, Hironobu Ihn, Yasuko Murakami, Senya Matsufuji, Kunio Fujiwara, Masashi Shin (2017). Histochem Cell Biol. 10.1007/s00418-017-1621-1
An overview of polyamine metabolism in pancreatic ductal adenocarcinoma. Otto Phanstiel (2017). Intl Journal of Cancer. 10.1002/ijc.31155
Investigation of Polyamine Metabolism and Homeostasis in Pancreatic Cancers. Chelsea Massaro, Jenna Thomas, Otto Phanstiel (2017). Medical Sciences. 10.3390/medsci5040032
Evaluation of Polyamine Transport Inhibitors in a Drosophila Epithelial Model Suggests the Existence of Multiple Transport Systems. Minpei Wang, Otto Phanstiel, Laurence Von Kalm (2017). Medical Sciences. 10.3390/medsci5040027
Spectroscopic and calorimetric characterization of spermine oxidase and its association forms. Alessia Leonetti, Laura Cervoni, Fabio Polticelli, Yuta Kanamori, Zuleyha Nihan Yurtsever, Enzo Agostinelli, Paolo Mariottini, Pasquale Stano, Manuela Cervelli (2017).10.1042/bcj20170744
Putrescine catabolism via DAO contributes to proline and GABA accumulation in roots of lupine seedlings growing under salt stress. Jolanta Legocka, Ewa Sobieszczuk-Nowicka, Damian Ludwicki, Teresa Lehmann (2017). Acta Soc Bot Pol. 10.5586/asbp.3549
2016
Ternary Hybrid γ‐Fe2O3/CrVI/Amine Oxidase Nanostructure for Electrochemical Sensing: Application for Polyamine Detection in Tumor Tissue. Emanuela Bonaiuto, Massimiliano Magro, Davide Baratella, Petr Jakubec, Elisabetta Sconcerle, Milo Terzo, Giovanni Miotto, Alberto Macone, Enzo Agostinelli, Silvano Fasolato, Rina Venerando, Gabriella Salviulo, Ondrej Malina, Radek Zboril, Fabio Vianello (2016). Chemistry A European J. 10.1002/chem.201600156
Naturally occurring branched-chain polyamines induce a crosslinked meshwork structure in a giant DNA. Akira Muramatsu, Yuta Shimizu, Yuko Yoshikawa, Wakao Fukuda, Naoki Umezawa, Yuhei Horai, Tsunehiko Higuchi, Shinsuke Fujiwara, Tadayuki Imanaka, Kenichi Yoshikawa (2016).10.1063/1.4972066
Spermine cycling in mitochondria is mediated by adenine nucleotide translocase activity: mechanism and pathophysiological implications. Silvia Grancara, Lisa Dalla Via, Aida Nelly García-Argáez, Shinji Ohkubo, Elena Pacella, Sabrina Manente, Marcantonio Bragadin, Antonio Toninello, Enzo Agostinelli (2016). Amino Acids. 10.1007/s00726-016-2264-6
Epigenetic silencing of miR-124 prevents spermine oxidase regulation: implications for Helicobacter pylori-induced gastric cancer. T Murray-Stewart, J C Sierra, M B Piazuelo, R M Mera, R Chaturvedi, L E Bravo, P Correa, B G Schneider, K T Wilson, R A Casero (2016). Oncogene. 10.1038/onc.2016.91
Synthesis of Self‐Assembled Spermidine‐Carbon Quantum Dots Effective against Multidrug‐Resistant Bacteria. Yu‐Jia Li, Scott G. Harroun, Yu‐Chia Su, Chun‐Fang Huang, Binesh Unnikrishnan, Han‐Jia Lin, Chia‐Hua Lin, Chih‐Ching Huang (2016). Adv Healthcare Materials. 10.1002/adhm.201600297
A suggested vital function for eIF‐5A and dhs genes during murine malaria blood‐stage infection. David Kersting, Mirko Krüger, Julia M. Sattler, Ann‐Kristin Mueller, Annette Kaiser (2016). FEBS Open Bio. 10.1002/2211-5463.12093
Novel hydroxylamine-containing analogues of 1-guanidino-7-aminoheptane (GC7), an effective inhibitor of deoxyhypusine synthase. M. A. Khomutov, A. R. Simonian, J. Weisell, J. Vepsalainen, S. N. Kochetkov, A. R. Khomutov (2016). Russ J Bioorg Chem. 10.1134/s1068162016040099
Synthesis of 2,11-bis(methylidene)spermine, a new inhibitor of spermine oxidase. N. A. Grigorenko, M. A. Khomutov, A. R. Simonian, S. N. Kochetkov, A. R. Khomutov (2016). Russ J Bioorg Chem. 10.1134/s1068162016030080
Triethylenetetramine modulates polyamine and energy metabolism and inhibits cancer cell proliferation. Mervi T. Hyvönen, Sebahat Ucal, Markku Pasanen, Sirpa Peräniemi, Janne Weisell, Maxim Khomutov, Alex R. Khomutov, Jouko Vepsäläinen, Leena Alhonen, Tuomo A. Keinänen (2016).10.1042/bcj20160134
Two stems with different characteristics and an internal loop in an RNA aptamer contribute to spermine-binding. Akihiro Oguro, Asumi Yanagida, Yuta Fujieda, Ryo Amano, Maina Otsu, Taiichi Sakamoto, Gota Kawai, Senya Matsufuji (2016). J Biochem. 10.1093/jb/mvw062
Polyamine Antagonist Therapies Inhibit Neuroblastoma Initiation and Progression. Nicholas F. Evageliou, Michelle Haber, Annette Vu, Theodore W. Laetsch, Jayne Murray, Laura D. Gamble, Ngan Ching Cheng, Kangning Liu, Megan Reese, Kelly A. Corrigan, David S. Ziegler, Hannah Webber, Candice S. Hayes, Bruce Pawel, Glenn M. Marshall, Huaqing Zhao, Susan K. Gilmour, Murray D. Norris, Michael D. Hogarty (2016).10.1158/1078-0432.ccr-15-2539
Ser/Thr kinases and polyamines in the regulation of non-canonical functions of elongation factor 1A. Nunzia Migliaccio, Nicola M. Martucci, Immacolata Ruggiero, Carmen Sanges, Shinji Ohkubo, Annalisa Lamberti, Enzo Agostinelli, Paolo Arcari (2016). Amino Acids. 10.1007/s00726-016-2311-3
Stability of spermine oxidase to thermal and chemical denaturation: comparison with bovine serum amine oxidase. Manuela Cervelli, Alessia Leonetti, Laura Cervoni, Shinji Ohkubo, Marla Xhani, Pasquale Stano, Rodolfo Federico, Fabio Polticelli, Paolo Mariottini, Enzo Agostinelli (2016). Amino Acids. 10.1007/s00726-016-2273-5
2015
Polyamines in conventional and organic vegetables exposed to exogenous ethylene. Maria Rosecler Miranda Rossetto, Fabio Vianello, Margarida Juri Saeki, Giuseppina Pace Pereira Lima (2015). Food Chemistry. 10.1016/j.foodchem.2015.04.125
A novel enzyme with spermine oxidase properties in bovine liver mitochondria: Identification and kinetic characterization. Emanuela Bonaiuto, Silvia Grancara, Pamela Martinis, Annarita Stringaro, Marisa Colone, Enzo Agostinelli, Alberto Macone, Roberto Stevanato, Fabio Vianello, Antonio Toninello, Maria Luisa Di Paolo (2015). Free Radical Biology and Medicine. 10.1016/j.freeradbiomed.2015.01.001
Pathophysiological implications of mitochondrial oxidative stress mediated by mitochondriotropic agents and polyamines: the role of tyrosine phosphorylation. Silvia Grancara, Francesca Zonta, Shinji Ohkubo, Anna Maria Brunati, Enzo Agostinelli, Antonio Toninello (2015). Amino Acids. 10.1007/s00726-015-1964-7
The Essential Role of Spermidine in Growth of Agrobacterium tumefaciens Is Determined by the 1,3-Diaminopropane Moiety. Sok Ho Kim, Yi Wang, Maxim Khomutov, Alexey Khomutov, Clay Fuqua, Anthony J. Michael (2015). ACS Chem. Biol.. 10.1021/acschembio.5b00893
Enantioselective synthesis of (R)- and (S)-3-methylspermidines. M. A. Khomutov, T. A. Keinanen, M. T. Hyvonen, J. Weisell, J. Vepsalainen, L. Alhonen, S. N. Kochetkov, A. R. Khomutov (2015). Russ J Bioorg Chem. 10.1134/s1068162015050064
Enantiomers of 3-Methylspermidine Selectively Modulate Deoxyhypusine Synthesis and Reveal Important Determinants for Spermidine Transport. Mervi T. Hyvönen, Maxim Khomutov, Marine Petit, Janne Weisell, Sergey N. Kochetkov, Leena Alhonen, Jouko Vepsäläinen, Alex R. Khomutov, Tuomo A. Keinänen (2015). ACS Chem. Biol.. 10.1021/cb500938e
Inhibition of Polyamine Uptake Potentiates the Anti‐Proliferative Effect of Polyamine Synthesis Inhibition and Preserves the Contractile Phenotype of Vascular Smooth Muscle Cells. Mario Grossi, Otto Phanstiel, Catarina Rippe, Karl Swärd, Azra Alajbegovic, Sebastian Albinsson, Amalia Forte, Lo Persson, Per Hellstrand, Bengt‐Olof Nilsson (2015). Journal Cellular Physiology. 10.1002/jcp.25236
Bioconjugation of gold-polymer core–shell nanoparticles with bovine serum amine oxidase for biomedical applications. I. Venditti, T.F. Hassanein, I. Fratoddi, L. Fontana, C. Battocchio, F. Rinaldi, M. Carafa, C. Marianecci, M. Diociaiuti, E. Agostinelli, C. Cametti, M.V. Russo (2015). Colloids and Surfaces B: Biointerfaces. 10.1016/j.colsurfb.2015.06.052
Lead-stress induced changes in the content of free, thylakoid- and chromatin-bound polyamines, photosynthetic parameters and ultrastructure in greening barley leaves. Jolanta Legocka, Ewa Sobieszczuk-Nowicka, Łukasz Wojtyla, Sławomir Samardakiewicz (2015). Journal of Plant Physiology. 10.1016/j.jplph.2015.07.010
2014
Nanoparticle strategies for cancer therapeutics: Nucleic acids, polyamines, bovine serum amine oxidase and iron oxide nanoparticles (Review). ENZO AGOSTINELLI, FABIO VIANELLO, GIUSEPPE MAGLIULO, THRESIA THOMAS, T.J. THOMAS (2014).10.3892/ijo.2014.2706
Long-Chain and Branched Polyamines in Thermophilic Microbes. Wakao Fukuda, Ryota Hidese, Shinsuke Fujiwara (2014).10.1007/978-4-431-55212-3_2
Protein Synthesis and Polyamines in Thermophiles: Effect of Polyamines on Nucleic Acid Maintenance and Gene Expression. Shinsuke Fujiwara, Ryota Hidese, Takahiro Inoue, Wakao Fukuda (2014).10.1007/978-4-431-55212-3_12
Identification of a Novel Aminopropyltransferase Involved in the Synthesis of Branched-Chain Polyamines in Hyperthermophiles. Kazuma Okada, Ryota Hidese, Wakao Fukuda, Masaru Niitsu, Koichi Takao, Yuhei Horai, Naoki Umezawa, Tsunehiko Higuchi, Tairo Oshima, Yuko Yoshikawa, Tadayuki Imanaka, Shinsuke Fujiwara (2014). J Bacteriol. 10.1128/jb.01515-14
Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase. R Chaturvedi, T de Sablet, M Asim, M B Piazuelo, D P Barry, T G Verriere, J C Sierra, D M Hardbower, A G Delgado, B G Schneider, D A Israel, J Romero-Gallo, T A Nagy, D R Morgan, T Murray-Stewart, L E Bravo, R M Peek, J G Fox, P M Woster, R A Casero, P Correa, K T Wilson (2014). Oncogene. 10.1038/onc.2014.273
Polyamine-Blocking Therapy Reverses Immunosuppression in the Tumor Microenvironment. Candace S. Hayes, Allyson C. Shicora, Martin P. Keough, Adam E. Snook, Mark R. Burns, Susan K. Gilmour (2014).10.1158/2326-6066.cir-13-0120-t
The combined treatment with chloroquine and the enzymatic oxidation products of spermine overcomes multidrug resistance of melanoma M14 ADR2 cells: A new therapeutic approach. ENZO AGOSTINELLI, MARIA CONDELLO, GIAMPIERO TEMPERA, ALBERTO MACONE, GIUSEPPINA BOZZUTO, SHINJI OHKUBO, ANNARICA CALCABRINI, GIUSEPPE ARANCIA, AGNESE MOLINARI (2014).10.3892/ijo.2014.2502
Polyamines and transglutaminases: biological, clinical, and biotechnological perspectives. Enzo Agostinelli (2014). Amino Acids. 10.1007/s00726-014-1688-0
Polyamines are common players in different facets of plant programmed cell death. G. Cai, E. Sobieszczuk-Nowicka, I. Aloisi, L. Fattorini, D. Serafini-Fracassini, S. Del Duca (2014). Amino Acids. 10.1007/s00726-014-1865-1
2013
Bidirectional fluxes of spermine across the mitochondrial membrane. Silvia Grancara, Pamela Martinis, Sabrina Manente, Aida Nelly García-Argáez, Giampiero Tempera, Marcantonio Bragadin, Lisa Dalla Via, Enzo Agostinelli, Antonio Toninello (2013). Amino Acids. 10.1007/s00726-013-1591-0
Commentary on: Hairless and the polyamine putrescine form a negative regulatory loop in the epidermis. Yuval Ramot, Leah A. Vardy (2013). Experimental Dermatology. 10.1111/exd.12244
Spermine oxidase is a regulator of macrophage host response to Helicobacter pylori: enhancement of antimicrobial nitric oxide generation by depletion of spermine. Rupesh Chaturvedi, Mohammad Asim, Daniel P. Barry, Jeanetta W. Frye, Robert A. Casero, Keith T. Wilson (2013). Amino Acids. 10.1007/s00726-013-1531-z
Duplication and Diversification of the Spermidine/Spermine N1-acetyltransferase 1 Genes in Zebrafish. Yi-Chin Lien, Ting-Yu Ou, Yu-Tzu Lin, Po-Chih Kuo, Han-Jia Lin (2013). PLoS ONE. 10.1371/journal.pone.0054017
Hydroxylamine derivatives for regulation of spermine and spermidine metabolism. M. A. Khomutov, J. Weisell, M. Hyvönen, T. A. Keinänen, J. Vepsäläinen, L. Alhonen, A. R. Khomutov, S. N. Kochetkov (2013). Biochemistry Moscow. 10.1134/s0006297913130051
Multiple forms of mouse antizyme inhibitor 1 mRNA differentially regulated by polyamines. Yasuko Murakami, Makiko Ohkido, Hiroko Takizawa, Noriyuki Murai, Senya Matsufuji (2013). Amino Acids. 10.1007/s00726-013-1598-6
Putrescine Importer PlaP Contributes to Swarming Motility and Urothelial Cell Invasion in Proteus mirabilis. Shin Kurihara(栗原新), Yumi Sakai(坂井友美), Hideyuki Suzuki(鈴木秀之), Aaron Muth, Otto Phanstiel, Philip N. Rather (2013). Journal of Biological Chemistry. 10.1074/jbc.m113.454090
Innovative approaches to the use of polyamines for DNA nanoparticle preparation for gene therapy. Veena Vijayanathan, Enzo Agostinelli, Thresia Thomas, T. J. Thomas (2013). Amino Acids. 10.1007/s00726-013-1549-2
Spermine metabolism and radiation-derived reactive oxygen species for future therapeutic implications in cancer: an additive or adaptive response. Roberto Amendola, Manuela Cervelli, Giampiero Tempera, Emiliano Fratini, Luigi Varesio, Paolo Mariottini, Enzo Agostinelli (2013). Amino Acids. 10.1007/s00726-013-1579-9
Reactive oxygen species spermine metabolites generated from amine oxidases and radiation represent a therapeutic gain in cancer treatments. ROBERTO AMENDOLA, MANUELA CERVELLI, EMILIANO FRATINI, DAVIDE E. SALLUSTIO, GIAMPIERO TEMPERA, TAICHI UESHIMA, PAOLO MARIOTTINI, ENZO AGOSTINELLI (2013).10.3892/ijo.2013.2013
MDL 72527 and spermine oxidation products induce a lysosomotropic effect and mitochondrial alterations in tumour cells. Enzo Agostinelli, Giampiero Tempera, Laura Dalla Vedova, Maria Condello, Giuseppe Arancia (2013).10.1042/bst0411773u
Novel polyamine analogues: From substrates towards potential inhibitors of monoamine oxidases. Emanuela Bonaiuto, Andrea Milelli, Giorgio Cozza, Vincenzo Tumiatti, Chiara Marchetti, Enzo Agostinelli, Carmela Fimognari, Patrizia Hrelia, Anna Minarini, Maria Luisa Di Paolo (2013). European Journal of Medicinal Chemistry. 10.1016/j.ejmech.2013.07.005
Plastid‐associated polyamines: their role in differentiation, structure, functioning, stress response and senescence. E. Sobieszczuk‐Nowicka, J. Legocka (2013). Plant Biol J. 10.1111/plb.12058
2012
Catalytically active bovine serum amine oxidase bound to fluorescent and magnetically drivable nanoparticles. Fabio Vianello, Sinigaglia, Magro, Miotto, Cardillo, Agostinelli, Zboril, Bidollari (2012). IJN. 10.2147/ijn.s28237
Erratum to: Preliminary kinetic characterization of a copper amine oxidase from rat liver mitochondria matrix. Roberto Stevanato, Sara Cardillo, Michele Braga, Angela De Iuliis, Valentina Battaglia, Antonio Toninello, Enzo Agostinelli, Fabio Vianello (2012). Amino Acids. 10.1007/s00726-012-1227-9
AMD1 is essential for ESC self-renewal and is translationally down-regulated on differentiation to neural precursor cells. Dawei Zhang, Tianyun Zhao, Haw Siang Ang, Peini Chong, Ryotaro Saiki, Kazuei Igarashi, Henry Yang, Leah A. Vardy (2012). Genes Dev.. 10.1101/gad.182998.111
Editorial: Orchestration of macrophage polarization by polyamines. Alain P Gobert, Keith T Wilson (2012).10.1189/jlb.0112047
L-arginine uptake by cationic amino acid transporter 2 is essential for colonic epithelial cell restitution. Kshipra Singh, Lori A. Coburn, Daniel P. Barry, Jean-Luc Boucher, Rupesh Chaturvedi, Keith T. Wilson (2012). American Journal of Physiology-Gastrointestinal and Liver Physiology. 10.1152/ajpgi.00544.2011
Spermine oxidase, a polyamine catabolic enzyme that linksHelicobacter pyloriCagA and gastric cancer risk. Rupesh Chaturvedi, Thibaut de Sablet, Richard M. Peek, Keith T. Wilson (2012). Gut Microbes. 10.4161/gmic.19345
In vitro and in vivo silencing of plasmodial dhs and eIf-5a genes in a putative, non-canonical RNAi-related pathway. Andreas Schwentke, Marcel Krepstakies, Ann-Kristin Mueller, Christiane Hammerschmidt-Kamper, Basma A Motaal, Tina Bernhard, Joachim Hauber, Annette Kaiser (2012). BMC Microbiol. 10.1186/1471-2180-12-107
Biogenic polyamines spermine and spermidine activate RNA polymerase and inhibit RNA helicase of hepatitis C virus. A. N. Korovina, V. L. Tunitskaya, M. A. Khomutov, A. R. Simonian, A. R. Khomutov, A. V. Ivanov, S. N. Kochetkov (2012). Biochemistry Moscow. 10.1134/s0006297912100094
Erratum to: Chronic exposure to agmatine results in the selection of agmatine-resistant hepatoma cells. Andrea Bandino, Valentina Battaglia, Vittoria Bravoco, Chiara Busletta, Alessandra Compagnone, Carlo Cravanzola, Floriana Meli, Enzo Agostinelli, Maurizio Parola, Sebastiano Colombatto (2012). Amino Acids. 10.1007/s00726-012-1241-y
2011
Do mammalian amine oxidases and the mitochondrial polyamine transporter have similar protein structures?. Enzo Agostinelli, Antonio Toninello, Fabio Vianello, Roberto Stevanato (2011). Amino Acids. 10.1007/s00726-011-0988-x
The structure of maize polyamine oxidase K300M mutant in complex with the natural substrates provides a snapshot of the catalytic mechanism of polyamine oxidation. Annarita Fiorillo, Rodolfo Federico, Fabio Polticelli, Alberto Boffi, Franco Mazzei, Massimo Di Fusco, Andrea Ilari, Paraskevi Tavladoraki (2011). The FEBS Journal. 10.1111/j.1742-4658.2010.08000.x
Further characterization of agmatine binding to mitochondrial membranes: involvement of imidazoline I2 receptor. Pamela Martinis, Valentina Battaglia, Silvia Grancara, Lisa Dalla Via, Vito Di Noto, Stefania Saccoccio, Enzo Agostinelli, Marcantonio Bragadin, Maria Angelica Grillo, Antonio Toninello (2011). Amino Acids. 10.1007/s00726-011-0992-1
Effect of peroxides on spermine transport in rat brain and liver mitochondria. Valentina Battaglia, Elena Tibaldi, Silvia Grancara, Francesca Zonta, Anna Maria Brunati, Pamela Martinis, Marcantonio Bragadin, Maria Angelica Grillo, Giampiero Tempera, Enzo Agostinelli, Antonio Toninello (2011). Amino Acids. 10.1007/s00726-011-0990-3
Arginine and polyamines in Helicobacter pylori-induced immune dysregulation and gastric carcinogenesis. Rupesh Chaturvedi, Thibaut de Sablet, Lori A. Coburn, Alain P. Gobert, Keith T. Wilson (2011). Amino Acids. 10.1007/s00726-011-1038-4
Spermine Oxidase Mediates the Gastric Cancer Risk Associated With Helicobacter pylori CagA. Rupesh Chaturvedi, Mohammad Asim, Judith Romero–Gallo, Daniel P. Barry, Svea Hoge, Thibaut de Sablet, Alberto G. Delgado, Lydia E. Wroblewski, M. Blanca Piazuelo, Fang Yan, Dawn A. Israel, Robert A. Casero, Pelayo Correa, Alain P. Gobert, D. Brent Polk, Richard M. Peek, Keith T. Wilson (2011). Gastroenterology. 10.1053/j.gastro.2011.07.045
Translational control of eIF5A in various diseases. Annette Kaiser (2011). Amino Acids. 10.1007/s00726-011-1042-8
Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A. Mervi T. Hyvönen, Tuomo A. Keinänen, Maxim Khomutov, Alina Simonian, Jouko Vepsäläinen, Jong Hwan Park, Alex R. Khomutov, Leena Alhonen, Myung Hee Park (2011). Amino Acids. 10.1007/s00726-011-0984-1
Leishmania donovani: Structural insignt in the recognition of C-methylated analogues of spermidine as natural polyamines. S. Mandal, M. A. Khomutov, A. R. Simonian, S. N. Kochetkov, R. Madhubala (2011). Mol Biol. 10.1134/s002689331104008x
The Use of Novel C-Methylated Spermidine Derivatives To Investigate the Regulation of Polyamine Metabolism. Mervi T. Hyvönen, Tuomo A. Keinänen, Maxim Khomutov, Alina Simonian, Janne Weisell, Sergey N. Kochetkov, Jouko Vepsäläinen, Leena Alhonen, Alex R. Khomutov (2011). J. Med. Chem.. 10.1021/jm200293r
Novel metabolically stable and functionally active mimetic of spermidine. M. A. Khomutov, M. T. Hyvönen, A. R. Simonian, J. Vepsäläinen, L. Alhonen, S. N. Kochetkov, T. A. Keinänen (2011). Russ J Bioorg Chem. 10.1134/s1068162011020075
Methylated Polyamines as Research Tools. Alex R. Khomutov, Janne Weisell, Maxim A. Khomutov, Nikolay A. Grigorenko, Alina R. Simonian, Merja R. Häkkinen, Tuomo A. Keinänen, Mervi T. Hyvönen, Leena Alhonen, Sergey N. Kochetkov, Jouko Vepsäläinen (2011).10.1007/978-1-61779-034-8_29
Defining the role of polyamines in colon carcinogenesis using mouse models. NataliaA Ignatenko, EugeneW Gerner, DavidG Besselsen (2011). J Carcinog. 10.4103/1477-3163.79673
A prolonged and exaggerated wound response with elevated ODC activity mimics early tumor development. Candace S. Hayes, Karen DeFeo, Hong Dang, Carol S. Trempus, Rebecca J. Morris, Susan K. Gilmour (2011).10.1093/carcin/bgr129
Role of polyamines, their analogs and transglutaminases in biological and clinical perspectives. Enzo Agostinelli (2011). Amino Acids. 10.1007/s00726-011-1129-2
Novel Reversible Monoamine Oxidase A Inhibitors: Highly Potent and Selective 3-(1H-Pyrrol-3-yl)-2-oxazolidinones. Sergio Valente, Stefano Tomassi, Giampiero Tempera, Stefania Saccoccio, Enzo Agostinelli, Antonello Mai (2011). J. Med. Chem.. 10.1021/jm201011x
2010
Preliminary kinetic characterization of a copper amine oxidase from rat liver mitochondria matrix. Roberto Stevanato, Sara Cardillo, Michele Braga, Angela De Iuliis, Valentina Battaglia, Antonio Toninello, Enzo Agostinelli, Fabio Vianello (2010). Amino Acids. 10.1007/s00726-010-0708-y
Increased expression and cellular localization of spermine oxidase in ulcerative colitis and relationship to disease activity. Shih-Kuang S. Hong, Rupesh Chaturvedi, Blanca M. Piazuelo, Lori A. Coburn, Christopher S. Williams, Alberto G. Delgado, Robert A. Casero, David A. Schwartz, Keith T. Wilson (2010). Inflammatory Bowel Diseases. 10.1002/ibd.21224
Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production. Rupesh Chaturvedi, Mohammad Asim, Svea Hoge, Nuruddeen D. Lewis, Kshipra Singh, Daniel P. Barry, Thibaut de Sablet, M. Blanca Piazuelo, Aditya R. Sarvaria, Yulan Cheng, Ellen I. Closs, Robert A. Casero, Alain P. Gobert, Keith T. Wilson (2010). Gastroenterology. 10.1053/j.gastro.2010.06.060
A high-throughput colorimetric assay to characterize the enzyme kinetic and cellular activity of spermidine/spermine N1-acetyltransferase 1. Han-Jia Lin, Yi-Chin Lien, Chun-Hua Hsu (2010). Analytical Biochemistry. 10.1016/j.ab.2010.07.036