Polyamines Papers

    2024

  • Identification and enzymatic properties of arginine decarboxylase from
    Aspergillus oryzae
    . Yui Murakami, Soichiro Ikuta, Wakao Fukuda, Naoki Akasaka, Jun-ichi Maruyama, Shuichi Shinma, Eiichiro Fukusaki, Shinsuke Fujiwara (2024). Appl Environ Microbiol. 10.1128/aem.00294-24
  • Prenatal nicotine exposure leads to epigenetic alterations in peripheral nervous system signaling genes in the testis of the rat. Ouzna Dali, Jose Antonio Muriel-Muriel, Ana Vargas-Baco, Sergei Tevosian, Jasenka Zubcevic, Fatima Smagulova, Linda F. Hayward (2024). Epigenetics & Chromatin. 10.1186/s13072-024-00539-5
  • Polyamine Pathway Inhibitor DENSPM Suppresses Lipid Metabolism in Pheochromocytoma Cell Line. Hans K. Ghayee, Kaylie A. Costa, Yiling Xu, Heather M. Hatch, Mateo Rodriguez, Shelby C. Straight, Marian Bustamante, Fahong Yu, Fatima Smagulova, John A. Bowden, Sergei G. Tevosian (2024). IJMS. 10.3390/ijms251810029
  • Spermine oxidase promotes Helicobacter pylori-mediated gastric carcinogenesis through acrolein production. Kara M. McNamara, Johanna C. Sierra, Yvonne L. Latour, Caroline V. Hawkins, Mohammad Asim, Kamery J. Williams, Daniel P. Barry, Margaret M. Allaman, Irene Zagol-Ikapitte, Paula B. Luis, Claus Schneider, Alberto G. Delgado, M. Blanca Piazuelo, Regina N. Tyree, Kate S. Carson, Yash A. Choksi, Lori A. Coburn, Alain P. Gobert, Keith T. Wilson (2024). Oncogene. 10.1038/s41388-024-03218-7
  • Enhancing the Spermidine Synthase-Based Polyamine Biosynthetic Pathway to Boost Rapid Growth in Marine Diatom Phaeodactylum tricornutum. Hung-Yun Lin, Chung-Hsiao Liu, Yong-Ting Kang, Sin-Wei Lin, Hsin-Yun Liu, Chun-Ting Lee, Yu-Chen Liu, Man-Chun Hsu, Ya-Yun Chien, Shao-Ming Hong, Yun-Hsuan Cheng, Bing-You Hsieh, Han-Jia Lin (2024). Biomolecules. 10.3390/biom14030372
  • The Development of LAT1 Efflux Agonists as Mechanistic Probes of Cellular Amino Acid Stress. Vandana Sekhar, Houssine Ikhlef, Alexandra Bunea, Viet S. Nguyen, Johan Joo, Mukund P. Tantak, Holly Moots, Otto Phanstiel (2024). Biomolecules. 10.3390/biom14030326
  • Impact of Difluoromethylornithine and AMXT 1501 on Gene Expression and Capsule Regulation in Streptococcus pneumoniae. Moses B. Ayoola, Leslie A. Shack, Otto Phanstiel, Bindu Nanduri (2024). Biomolecules. 10.3390/biom14020178

    2023

  • Spermine Oxidase–Substrate Electrostatic Interactions: The Modulation of Enzyme Function by Neighboring Colloidal ɣ-Fe2O3. Graziano Rilievo, Massimiliano Magro, Federica Tonolo, Alessandro Cecconello, Lavinia Rutigliano, Aura Cencini, Simone Molinari, Maria Luisa Di Paolo, Cristian Fiorucci, Marianna Nicoletta Rossi, Manuela Cervelli, Fabio Vianello (2023). Biomolecules. 10.3390/biom13121800
  • Growth-promoting and low-salt adaptation responses boosted by spermidine in Strombidium parasulcatum, a marine bacteriovorous ciliate potentially applied to live feeds for marine larviculture. Hung-Yun Lin, Bo-Ying Su, Nodali Ndraha, Sheng-Fang Tsai, Kuo-Ping Chiang, Hsin-Yun Liu, Yong-Ting Kang, Wei-Yu Yeh, Che-Chia Tsao, Yi-Min Chen, Hsin-I Hsiao, Han-Jia Lin (2023). Aquaculture. 10.1016/j.aquaculture.2023.739616
  • The Role of Spermidine and Its Key Metabolites in Important, Pathogenic Human Viruses and in Parasitic Infections Caused by Plasmodium falciparum and Trypanosoma brucei. Annette Kaiser (2023). Biomolecules. 10.3390/biom13050803
  • An Undefined Interaction between Polyamines and Heat Shock Proteins Leads to Cellular Protection in Plasmodium falciparum and Proliferating Cells in Various Organisms. Xolani H. Makhoba, Rino Ragno, Annette Kaiser, Enzo Agostinelli (2023). Molecules. 10.3390/molecules28041686
  • Difluoromethylornithine rebalances aberrant polyamine ratios in Snyder–Robinson syndrome. Tracy Murray Stewart, Jackson R Foley, Cassandra E Holbert, Maxim Khomutov, Noushin Rastkari, Xianzun Tao, Alex R Khomutov, R Grace Zhai, Robert A Casero (2023). EMBO Mol Med. 10.15252/emmm.202317833
  • C-Methylated Spermidine Derivatives: Convenient Syntheses and Antizyme-Related Effects. Maxim A. Khomutov, Arthur I. Salikhov, Vladimir A. Mitkevich, Vera L. Tunitskaya, Olga A. Smirnova, Sergey P. Korolev, Alexander O. Chizhov, Marina B. Gottikh, Sergey N. Kochetkov, Alex R. Khomutov (2023). Biomolecules. 10.3390/biom13060916
  • Inhibition of nicotinic acetylcholine receptors by oligoarginine peptides and polyamine-related compounds. Lucy O. Ojomoko, Elena V. Kryukova, Natalya S. Egorova, Arthur I. Salikhov, Lyubov A. Epifanova, Daria A. Denisova, Alex R. Khomutov, Dmitry A. Sukhov, Alexander A. Vassilevski, Maxim A. Khomutov, Victor I. Tsetlin, Irina V. Shelukhina (2023). Front. Pharmacol.. 10.3389/fphar.2023.1327603
  • Rebalancing polyamine levels to treat Snyder–Robinson syndrome. Susan K Gilmour (2023). EMBO Mol Med. 10.15252/emmm.202318506
  • Polyamines as Universal Bioregulators across Kingdoms and Their role in Cellular Longevity and Death. Ewelina Stolarska, Ewelina Paluch-Lubawa, Magda Grabsztunowicz, Umesh Kumar Tanwar, Magdalena Arasimowicz-Jelonek, Otto Phanstiel, Autar K. Mattoo, Ewa Sobieszczuk-Nowicka (2023). Critical Reviews in Plant Sciences. 10.1080/07352689.2023.2247886
  • Genetic portrait of polyamine transporters in barley: insights in the regulation of leaf senescence. Ewelina Stolarska, Umesh Kumar Tanwar, Yufeng Guan, Magda Grabsztunowicz, Magdalena Arasimowicz-Jelonek, Otto Phanstiel, Ewa Sobieszczuk-Nowicka (2023). Front. Plant Sci.. 10.3389/fpls.2023.1194737
  • Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation. Sonia Coni, Rosa Bordone, Devon Michael Ivy, Zuleyha Nihan Yurtsever, Laura Di Magno, Rodrigo D’Amico, Bianca Cesaro, Alessandro Fatica, Francesca Belardinilli, Francesca Bufalieri, Marella Maroder, Enrico De Smaele, Lucia Di Marcotullio, Giuseppe Giannini, Enzo Agostinelli, Gianluca Canettieri (2023). Cancer Letters. 10.1016/j.canlet.2023.216120
  • Editorial: Polyamines and longevity – role of polyamine in plant survival. Luigi Parrotta, Ewa Sobieszczuk-Nowicka, Giampiero Cai (2023). Front. Plant Sci.. 10.3389/fpls.2023.1232386

    2022

  • Acidic Shift of Optimum pH of Bovine Serum Amine Oxidase upon Immobilization onto Nanostructured Ferric Tannates. Graziano Rilievo, Alessandro Cecconello, Simone Molinari, Andrea Venerando, Lavinia Rutigliano, Gayathri T. Govardhan, Dinusha H. Kariyawasam, Ruth J. Arusei, Lucio Zennaro, Maria L. Di Paolo, Enzo Agostinelli, Fabio Vianello, Massimiliano Magro (2022). IJMS. 10.3390/ijms232012172
  • Substrate Specificity of an Aminopropyltransferase and the Biosynthesis Pathway of Polyamines in the Hyperthermophilic Crenarchaeon Pyrobaculum calidifontis. Wakao Fukuda, Mamoru Osaki, Yusuke Yasuda, Ryota Hidese, Tsunehiko Higuchi, Naoki Umezawa, Shinsuke Fujiwara, Eiichi Mizohata (2022). Catalysts. 10.3390/catal12050567
  • Ornithine Decarboxylase in Gastric Epithelial Cells Promotes the Immunopathogenesis of Helicobacter pylori Infection. Yvonne L. Latour, Johanna C. Sierra, Kara M. McNamara, Thaddeus M. Smith, Paula B. Luis, Claus Schneider, Alberto G. Delgado, Daniel P. Barry, Margaret M. Allaman, M. Wade Calcutt, Kevin L. Schey, M. Blanca Piazuelo, Alain P. Gobert, Keith T. Wilson (2022).10.4049/jimmunol.2100795
  • Protective Role of Spermidine in Colitis and Colon Carcinogenesis. Alain P. Gobert, Yvonne L. Latour, Mohammad Asim, Daniel P. Barry, Margaret M. Allaman, Jordan L. Finley, Thaddeus M. Smith, Kara M. McNamara, Kshipra Singh, Johanna C. Sierra, Alberto G. Delgado, Paula B. Luis, Claus Schneider, M. Kay Washington, M. Blanca Piazuelo, Shilin Zhao, Lori A. Coburn, Keith T. Wilson (2022). Gastroenterology. 10.1053/j.gastro.2021.11.005
  • Specific and sensitive GC–MS analysis of hypusine, Nε-(4-amino-2-hydroxybutyl)lysine, a biomarker of hypusinated eukaryotic initiation factor eIF5A, and its application to the bi-ethnic ASOS study. Svetlana Baskal, Annette Kaiser, Catharina Mels, Ruan Kruger, Dimitrios Tsikas (2022). Amino Acids. 10.1007/s00726-022-03142-8
  • Investigation of an Allosteric Deoxyhypusine Synthase Inhibitor in P. falciparum. Aiyada Aroonsri, Chayaphat Wongsombat, Philip Shaw, Siegrid Franke, Jude Przyborski, Annette Kaiser (2022). Molecules. 10.3390/molecules27082463
  • Hypusinated EIF5A as a feasible drug target for Advanced Medicinal Therapies in the treatment of pathogenic parasites and therapy-resistant tumors. Annette Kaiser, Enzo Agostinelli (2022). Amino Acids. 10.1007/s00726-021-03120-6
  • Synthesis of 2-Methylidene Spermidine and its N1-Acetylated Derivative. M. A. Khomutov, A. R. Khomutov (2022). Russ J Bioorg Chem. 10.1134/s1068162022060140
  • Role of Polyamine-Induced Dimerization of Antizyme in Its Cellular Functions. Mervi T. Hyvönen, Olga A. Smirnova, Vladimir A. Mitkevich, Vera L. Tunitskaya, Maxim Khomutov, Dmitry S. Karpov, Sergey P. Korolev, Merja R. Häkkinen, Marko Pietilä, Marina B. Gottikh, Jouko Vepsäläinen, Leena Alhonen, Alexander A. Makarov, Sergey N. Kochetkov, Heather M. Wallace, Tuomo A. Keinänen, Alex R. Khomutov (2022). IJMS. 10.3390/ijms23094614
  • Difluoromethylornithine (DFMO) Enhances the Cytotoxicity of PARP Inhibition in Ovarian Cancer Cells. Olivia El Naggar, Brenna Doyle, Kelsey Mariner, Susan K. Gilmour (2022). Medical Sciences. 10.3390/medsci10020028
  • Difluoromethylornithine (DFMO) and AMXT 1501 inhibit capsule biosynthesis in pneumococci. Moses B. Ayoola, Leslie A. Shack, Jung Hwa Lee, Juhyeon Lim, Hyungjin Eoh, Edwin Swiatlo, Otto Phanstiel, Bindu Nanduri (2022). Sci Rep. 10.1038/s41598-022-16007-7
  • ATP13A3 facilitates polyamine transport in human pancreatic cancer cells. Vandana Sekhar, Thomas Andl, Otto Phanstiel (2022). Sci Rep. 10.1038/s41598-022-07712-4
  • Elucidating the Role of Chmp1 Overexpression in the Transport of Polyamines in Drosophila melanogaster. Coryn L. Stump, Robert A. Casero, Otto Phanstiel, Justin R. DiAngelo, Shannon L. Nowotarski (2022). Medical Sciences. 10.3390/medsci10030045
  • Polyamine-Based Nanostructures Share Polyamine Transport Mechanisms with Native Polyamines and Their Analogues: Significance for Polyamine-Targeted Therapy. Cassandra E. Holbert, Jackson R. Foley, Ao Yu, Tracy Murray Stewart, Otto Phanstiel, David Oupicky, Robert A. Casero (2022). Medical Sciences. 10.3390/medsci10030044
  • Bovine Serum Amine Oxidase and Polyamine Analogues: Chemical Synthesis and Biological Evaluation Integrated with Molecular Docking and 3-D QSAR Studies. Rino Ragno, Anna Minarini, Eleonora Proia, Antonini Lorenzo, Andrea Milelli, Vincenzo Tumiatti, Marco Fiore, Pasquale Fino, Lavinia Rutigliano, Rossella Fioravanti, Tomoaki Tahara, Elena Pacella, Antonio Greco, Gianluca Canettieri, Maria Luisa Di Paolo, Enzo Agostinelli (2022). J. Chem. Inf. Model.. 10.1021/acs.jcim.2c00559
  • Anticancer Cytotoxic Activity of Bispidine Derivatives Associated with the Increasing Catabolism of Polyamines. Ekaterina V. Neborak, Altynay B. Kaldybayeva, Lylia Bey, Aigul Y. Malmakova, Anna S. Tveritinova, Abdullah Hilal, Valentina K. Yu, Maria V. Ploskonos, Marina V. Komarova, Enzo Agostinelli, Dmitry D. Zhdanov (2022). Molecules. 10.3390/molecules27123872
  • Plant homocysteine, a methionine precursor and plant’s hallmark of metabolic disorders. Ewa Sobieszczuk-Nowicka, Magdalena Arasimowicz-Jelonek, Umesh Kumar Tanwar, Jolanta Floryszak-Wieczorek (2022). Front. Plant Sci.. 10.3389/fpls.2022.1044944
  • Comparative genomic analysis of the aldehyde dehydrogenase gene superfamily in Arabidopsis thaliana – searching for the functional key to hypoxia tolerance. Yufeng Guan, Umesh Kumar Tanwar, Ewa Sobieszczuk-Nowicka, Jolanta Floryszak-Wieczorek, Magdalena Arasimowicz-Jelonek (2022). Front. Plant Sci.. 10.3389/fpls.2022.1000024

    2021

  • The Polyamine Regulator AMD1 Upregulates Spermine Levels to Drive Epidermal Differentiation. Anisa B. Rahim, Hui Kheng Lim, Christina Yan Ru Tan, Li Jia, Vonny Ivon Leo, Takeshi Uemura, Jonathan Hardman-Smart, John E.A. Common, Thiam Chye Lim, Sophie Bellanger, Ralf Paus, Kazuei Igarashi, Henry Yang, Leah A. Vardy (2021). Journal of Investigative Dermatology. 10.1016/j.jid.2021.01.039
  • Ornithine decarboxylase (ODC1) gene variant (rs2302615) is associated with gastric cancer independently of Helicobacter pylori CagA serostatus. Anna K. Miller, Gloria Tavera, Ricardo L. Dominguez, M. Constanza Camargo, Tim Waterboer, Keith T. Wilson, Scott M. Williams, Douglas R. Morgan (2021). Oncogene. 10.1038/s41388-021-01981-5
  • The role of polyamines in gastric cancer. Kara M. McNamara, Alain P. Gobert, Keith T. Wilson (2021). Oncogene. 10.1038/s41388-021-01862-x
  • Toxic or Not Toxic, That Is the Carbon Quantum Dot’s Question: A Comprehensive Evaluation with Zebrafish Embryo, Eleutheroembryo, and Adult Models. Chih-Yu Chung, Yu-Ju Chen, Chia-Hui Kang, Hung-Yun Lin, Chih-Ching Huang, Pang-Hung Hsu, Han-Jia Lin (2021). Polymers. 10.3390/polym13101598
  • α-Difluoromethylornithine-Induced Cytostasis is Reversed by Exogenous Polyamines, Not by Thymidine Supplementation. Mervi T. Hyvönen, Maxim Khomutov, Jouko Vepsäläinen, Alex R. Khomutov, Tuomo A. Keinänen (2021). Biomolecules. 10.3390/biom11050707
  • DFMO Improves Survival and Increases Immune Cell Infiltration in Association with MYC Downregulation in the Pancreatic Tumor Microenvironment. Sai Preethi Nakkina, Sarah B. Gitto, Jordan M. Beardsley, Veethika Pandey, Michael W. Rohr, Jignesh G. Parikh, Otto Phanstiel, Deborah A. Altomare (2021). IJMS. 10.3390/ijms222413175
  • Development of a Redox-Sensitive Spermine Prodrug for the Potential Treatment of Snyder Robinson Syndrome. Mukund P. Tantak, Vandana Sekhar, Xianzun Tao, R. Grace Zhai, Otto Phanstiel (2021). J. Med. Chem.. 10.1021/acs.jmedchem.1c00419
  • Uptake of Biotinylated Spermine in Astrocytes: Effect of Cx43 siRNA, HIV-Tat Protein and Polyamine Transport Inhibitor on Polyamine Uptake. Christian J. Malpica-Nieves, Yomarie Rivera, David E. Rivera-Aponte, Otto Phanstiel, Rüdiger W. Veh, Misty J. Eaton, Serguei N. Skatchkov (2021). Biomolecules. 10.3390/biom11081187
  • Translational control of polyamine metabolism by CNBP is required for Drosophila locomotor function. Sonia Coni, Federica A Falconio, Marta Marzullo, Marzia Munafò, Benedetta Zuliani, Federica Mosti, Alessandro Fatica, Zaira Ianniello, Rosa Bordone, Alberto Macone, Enzo Agostinelli, Alessia Perna, Tanja Matkovic, Stephan Sigrist, Gabriella Silvestri, Gianluca Canettieri, Laura Ciapponi (2021).10.7554/elife.69269
  • Enzymatic Spermine Metabolites Induce Apoptosis Associated with Increase of p53, caspase-3 and miR-34a in Both Neuroblastoma Cells, SJNKP and the N-Myc-Amplified Form IMR5. Yuta Kanamori, Alessia Finotti, Laura Di Magno, Gianluca Canettieri, Tomoaki Tahara, Fabio Timeus, Antonio Greco, Paola Tirassa, Jessica Gasparello, Pasquale Fino, Carlo Di Liegro, Patrizia Proia, Gabriella Schiera, Italia Di Liegro, Roberto Gambari, Enzo Agostinelli (2021). Cells. 10.3390/cells10081950

    2020

  • Nanotechnology-Based Strategies to Develop New Anticancer Therapies. Massimiliano Magro, Andrea Venerando, Alberto Macone, Gianluca Canettieri, Enzo Agostinelli, Fabio Vianello (2020). Biomolecules. 10.3390/biom10050735
  • The Polyamine Putrescine Promotes Human Epidermal Melanogenesis. Aishwarya Sridharan, Meng Shi, Vonny Ivon Leo, Nagavidya Subramaniam, Thiam Chye Lim, Takeshi Uemura, Kazuei Igarashi, Steven Thng Tien Guan, Nguan Soon Tan, Leah A. Vardy (2020). Journal of Investigative Dermatology. 10.1016/j.jid.2020.02.009
  • Spermine oxidase mediates Helicobacter pylori-induced gastric inflammation, DNA damage, and carcinogenic signaling. Johanna C. Sierra, M. Blanca Piazuelo, Paula B. Luis, Daniel P. Barry, Margaret M. Allaman, Mohammad Asim, Thomas A. Sebrell, Jordan L. Finley, Kristie L. Rose, Salisha Hill, Steven L. Holshouser, Robert A. Casero, John L. Cleveland, Patrick M. Woster, Kevin L. Schey, Diane Bimczok, Claus Schneider, Alain P. Gobert, Keith T. Wilson (2020). Oncogene. 10.1038/s41388-020-1304-6
  • Synthesis of (3R,10R)- and (3S,10S)-Diastereomers of 3,10-Dimethylspermine. M. A. Khomutov, M. T. Hyvönen, A. I. Salikhov, A. O. Chizhov, I. M. Ryzhov, S. N. Kochetkov, J. Vepsäläinen, T. A. Keinänen, A. R. Khomutov (2020). Russ J Bioorg Chem. 10.1134/s1068162020060126
  • Virion-Associated Polyamines Transmit with Bunyaviruses to Maintain Infectivity and Promote Entry. Vincent Mastrodomenico, Jeremy J. Esin, Shefah Qazi, Maxim A. Khomutov, Alexander V. Ivanov, Suchetana Mukhopadhyay, Bryan C. Mounce (2020). ACS Infect. Dis.. 10.1021/acsinfecdis.0c00402
  • (R,R)-1,12-Dimethylspermine can mitigate abnormal spermidine accumulation in Snyder–Robinson syndrome. Tracy Murray Stewart, Maxim Khomutov, Jackson R. Foley, Xin Guo, Cassandra E. Holbert, Tiffany T. Dunston, Charles E. Schwartz, Kathleen Gabrielson, Alexey Khomutov, Robert A. Casero (2020). Journal of Biological Chemistry. 10.1074/jbc.ra119.011572
  • Hydroxylamine Analogue of Agmatine: Magic Bullet for Arginine Decarboxylase. Mervi T. Hyvönen, Tuomo A. Keinänen, Gulgina K. Nuraeva, Dmitry V. Yanvarev, Maxim Khomutov, Elena N. Khurs, Sergey N. Kochetkov, Jouko Vepsäläinen, Alexander A. Zhgun, Alex R. Khomutov (2020). Biomolecules. 10.3390/biom10030406
  • Identification of a novel substrate-derived spermine oxidase inhibitor. T. T. Dunston, M. A. Khomutov, S. B. Gabelli, T. M. Stewart, J. R. Foley, S. N. Kochetkov, A. R. Khomutov, R. A. Casero Jr. (2020). Acta Naturae. 10.32607/actanaturae.10992
  • Translation efficiency affects the sequence-independent +1 ribosomal frameshifting by polyamines. Akihiro Oguro, Tomoaki Shigeta, Kodai Machida, Tomoaki Suzuki, Takeo Iwamoto, Senya Matsufuji, Hiroaki Imataka (2020).10.1093/jb/mvaa032
  • Polyamine Blocking Therapy Decreases Survival of Tumor-Infiltrating Immunosuppressive Myeloid Cells and Enhances the Antitumor Efficacy of PD-1 Blockade. Eric T. Alexander, Kelsey Mariner, Julia Donnelly, Otto Phanstiel, Susan K. Gilmour (2020).10.1158/1535-7163.mct-19-1116
  • Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation. Sonia Coni, Silvia Maria Serrao, Zuleyha Nihan Yurtsever, Laura Di Magno, Rosa Bordone, Camilla Bertani, Valerio Licursi, Zaira Ianniello, Paola Infante, Marta Moretti, Marialaura Petroni, Francesca Guerrieri, Alessandro Fatica, Alberto Macone, Enrico De Smaele, Lucia Di Marcotullio, Giuseppe Giannini, Marella Maroder, Enzo Agostinelli, Gianluca Canettieri (2020). Cell Death Dis. 10.1038/s41419-020-03174-6
  • Biochemical and pathophysiological properties of polyamines. Enzo Agostinelli (2020). Amino Acids. 10.1007/s00726-020-02821-8

    2019

  • The therapeutic and nutraceutical potential of agmatine, and its enhanced production using Aspergillus oryzae. Naoki Akasaka, Shinsuke Fujiwara (2019). Amino Acids. 10.1007/s00726-019-02720-7
  • The C‐terminal flexible region of branched‐chain polyamine synthase facilitates substrate specificity and catalysis. Ryota Hidese, Masataka Toyoda, Ken‐ichi Yoshino, Wakao Fukuda, Gita Adhirani Wihardja, Seigo Kimura, Junso Fujita, Masaru Niitsu, Tairo Oshima, Tadayuki Imanaka, Eiichi Mizohata, Shinsuke Fujiwara (2019). The FEBS Journal. 10.1111/febs.14949
  • PGC1α Inhibits Polyamine Synthesis to Suppress Prostate Cancer Aggressiveness. Lisa Kaminski, Stéphanie Torrino, Maeva Dufies, Zied Djabari, Romain Haider, François-René Roustan, Emilie Jaune, Kathiane Laurent, Nicolas Nottet, Jean-François Michiels, Maeva Gesson, Stéphane Rocchi, Nathalie M. Mazure, Matthieu Durand, Jean-François Tanti, Damien Ambrosetti, Stephan Clavel, Issam Ben-Sahra, Frédéric Bost (2019).10.1158/0008-5472.can-18-2043
  • Involvement of the biogenic active amine agmatine in mitochondrial membrane permeabilization and release of pro-apoptotic factors. Pamela Martinis, Silvia Grancara, Yuta Kanamori, Aída Nelly García-Argáez, Elena Pacella, Lisa Dalla Via, Antonio Toninello, Enzo Agostinelli (2019). Amino Acids. 10.1007/s00726-019-02791-6
  • The role of polyamines in the regulation of macrophage polarization and function. Yvonne L. Latour, Alain P. Gobert, Keith T. Wilson (2019). Amino Acids. 10.1007/s00726-019-02719-0
  • Bacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway. Alain P. Gobert, Yvonne L. Latour, Mohammad Asim, Jordan L. Finley, Thomas G. Verriere, Daniel P. Barry, Ginger L. Milne, Paula B. Luis, Claus Schneider, Emilio S. Rivera, Kristie Lindsey-Rose, Kevin L. Schey, Alberto G. Delgado, Johanna C. Sierra, M. Blanca Piazuelo, Keith T. Wilson (2019). mBio. 10.1128/mbio.02174-19
  • α-Difluoromethylornithine reduces gastric carcinogenesis by causing mutations in
    Helicobacter pylori cagY
    . Johanna C. Sierra, Giovanni Suarez, M. Blanca Piazuelo, Paula B. Luis, Dara R. Baker, Judith Romero-Gallo, Daniel P. Barry, Claus Schneider, Douglas R. Morgan, Richard M. Peek, Alain P. Gobert, Keith T. Wilson (2019). Proc. Natl. Acad. Sci. U.S.A.. 10.1073/pnas.1814497116
  • Unforeseen Possibilities To Investigate the Regulation of Polyamine Metabolism Revealed by Novel C-Methylated Spermine Derivatives. Maxim Khomutov, Mervi T. Hyvönen, Alina Simonian, Andrey A. Formanovsky, Irina V. Mikhura, Alexander O. Chizhov, Sergey N. Kochetkov, Leena Alhonen, Jouko Vepsäläinen, Tuomo A. Keinänen, Alex R. Khomutov (2019). J. Med. Chem.. 10.1021/acs.jmedchem.9b01666
  • C-Methylated Analogs of Spermine and Spermidine: Synthesis and Biological Activity. M. A. Khomutov, I. V. Mikhura, S. N. Kochetkov, A. R. Khomutov (2019). Russ J Bioorg Chem. 10.1134/s1068162019060207
  • Synthesis of (R)- and (S)-isomers of 2-methylspermidine. Maxim A. Khomutov, Alexander O. Chizhov, Sergey N. Kochetkov, Alex R. Khomutov (2019). Mendeleev Communications. 10.1016/j.mencom.2019.11.025
  • Polyamine-stimulation of arsenic-transformed keratinocytes. Eric T Alexander, Kelsey Mariner, Yelizaveta Borodyanskaya, Allyson Minton, Susan K Gilmour (2019).10.1093/carcin/bgz115
  • Polyamines: The possible missing link between mental disorders and epilepsy (Review). Giulia Baroli, Jonathan Sanchez, Enzo Agostinelli, Paolo Mariottini, Manuela Cervelli (2019). Int J Mol Med. 10.3892/ijmm.2019.4401
  • Maize polyamine oxidase in the presence of spermine/spermidine induces the apoptosis of LoVo human colon adenocarcinoma cells. Shinji Ohkubo, Romina Mancinelli, Selenia Miglietta, Alessandra Cona, Riccardo Angelini, Gianluca Canettieri, Demetrios Spandidos, Eugenio Gaudio, Enzo Agostinelli (2019). Int J Oncol. 10.3892/ijo.2019.4780
  • Polyamine Metabolism as a Therapeutic Target in Hedgehog-Driven Basal Cell Carcinoma and Medulloblastoma. Sonia Coni, Laura Di Magno, Silvia Maria Serrao, Yuta Kanamori, Enzo Agostinelli, Gianluca Canettieri (2019). Cells. 10.3390/cells8020150
  • Link between spermine oxidase and apoptosis antagonizing transcription factor: A new pathway in neuroblastoma. Emiliano Fratini, Manuela Cervelli, Paolo Mariottini, Yuta Kanamori, Roberto Amendola, Enzo Agostinelli (2019). Int J Oncol. 10.3892/ijo.2019.4878
  • Exploring the activity of polyamine analogues on polyamine and spermine oxidase: methoctramine, a potent and selective inhibitor of polyamine oxidase. Maria Luisa Di Paolo, Manuela Cervelli, Paolo Mariottini, Alessia Leonetti, Fabio Polticelli, Michela Rosini, Andrea Milelli, Filippo Basagni, Rina Venerando, Enzo Agostinelli, Anna Minarini (2019). Journal of Enzyme Inhibition and Medicinal Chemistry. 10.1080/14756366.2019.1584620
  • Polyamines – A New Metabolic Switch: Crosstalk With Networks Involving Senescence, Crop Improvement, and Mammalian Cancer Therapy. Ewa Sobieszczuk-Nowicka, Ewelina Paluch-Lubawa, Autar K. Mattoo, Magdalena Arasimowicz-Jelonek, Per L. Gregersen, Andrzej Pacak (2019). Front. Plant Sci.. 10.3389/fpls.2019.00859

    2018

  • Endogenous and food-derived polyamines: determination by electrochemical sensing. Davide Baratella, Emanuela Bonaiuto, Massimiliano Magro, Jessica de Almeida Roger, Yuta Kanamori, Giuseppina Pace Pereira Lima, Enzo Agostinelli, Fabio Vianello (2018). Amino Acids. 10.1007/s00726-018-2617-4
  • Branched‐Chain Polyamine Found in Hyperthermophiles Induces Unique Temperature‐Dependent Structural Changes in Genome‐Size DNA. Takashi Nishio, Yuko Yoshikawa, Wakao Fukuda, Naoki Umezawa, Tsunehiko Higuchi, Shinsuke Fujiwara, Tadayuki Imanaka, Kenichi Yoshikawa (2018). ChemPhysChem. 10.1002/cphc.201800396
  • Agmatine Production by Aspergillus oryzae Is Elevated by Low pH during Solid-State Cultivation. Naoki Akasaka, Saori Kato, Saya Kato, Ryota Hidese, Yutaka Wagu, Hisao Sakoda, Shinsuke Fujiwara (2018). Appl Environ Microbiol. 10.1128/aem.00722-18
  • MINDY1 Is a Downstream Target of the Polyamines and Promotes Embryonic Stem Cell Self-Renewal. Christina James, Tian Yun Zhao, Anisa Rahim, Parul Saxena, Nazreen Abdul Muthalif, Takeshi Uemura, Norihiro Tsuneyoshi, Sheena Ong, Kazuei Igarashi, Chin Yan Lim, Norris Ray Dunn, Leah A. Vardy (2018).10.1002/stem.2830
  • Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses. Kshipra Singh, Lori A. Coburn, Mohammad Asim, Daniel P. Barry, Margaret M. Allaman, Chanjuan Shi, M. Kay Washington, Paula B. Luis, Claus Schneider, Alberto G. Delgado, M. Blanca Piazuelo, John L. Cleveland, Alain P. Gobert, Keith T. Wilson (2018).10.1158/0008-5472.can-18-0116
  • Distinct Immunomodulatory Effects of Spermine Oxidase in Colitis Induced by Epithelial Injury or Infection. Alain P. Gobert, Nicole T. Al-Greene, Kshipra Singh, Lori A. Coburn, Johanna C. Sierra, Thomas G. Verriere, Paula B. Luis, Claus Schneider, Mohammad Asim, Margaret M. Allaman, Daniel P. Barry, John L. Cleveland, Christina E. Destefano Shields, Robert A. Casero, M. Kay Washington, M. Blanca Piazuelo, Keith T. Wilson (2018). Front. Immunol.. 10.3389/fimmu.2018.01242
  • Polyamines in Microalgae: Something Borrowed, Something New. Hung-Yun Lin, Han-Jia Lin (2018). Marine Drugs. 10.3390/md17010001
  • Detection of urinary spermine by using silver-gold/silver chloride nanozymes. Po-Chih Kuo, Chia-Wen Lien, Ju-Yi Mao, Binesh Unnikrishnan, Huan-Tsung Chang, Han-Jia Lin, Chih-Ching Huang (2018). Analytica Chimica Acta. 10.1016/j.aca.2018.01.018
  • Acetylated derivatives of C-methylated analogues of spermidine: synthesis and interaction with N1-acetylpolyamine oxidase. Maxim A. Khomutov, Mervi T. Hyvönen, Alina R. Simonian, Janne Weisell, Jouko Vepsäläinen, Leena Alhonen, Sergey N. Kochetkov, Tuomo A. Keinänen, Alex R. Khomutov (2018). Mendeleev Communications. 10.1016/j.mencom.2018.09.008
  • Polyamine flux suppresses histone lysine demethylases and enhances ID1 expression in cancer stem cells. Keisuke Tamari, Masamitsu Konno, Ayumu Asai, Jun Koseki, Kazuhiko Hayashi, Koichi Kawamoto, Noriyuki Murai, Senya Matsufuji, Fumiaki Isohashi, Taroh Satoh, Noriko Goto, Shinji Tanaka, Yuichiro Doki, Masaki Mori, Kazuhiko Ogawa, Hideshi Ishii (2018). Cell Death Discovery. 10.1038/s41420-018-0117-7
  • Novel ubiquitin-independent nucleolar c-Myc degradation pathway mediated by antizyme 2. Noriyuki Murai, Yasuko Murakami, Ayasa Tajima, Senya Matsufuji (2018). Sci Rep. 10.1038/s41598-018-21189-0
  • A Novel Polyamine-Targeted Therapy for BRAF Mutant Melanoma Tumors. Molly Peters, Allyson Minton, Otto Phanstiel IV, Susan Gilmour (2018). Medical Sciences. 10.3390/medsci6010003
  • Plant organ senescence – regulation by manifold pathways. N. Wojciechowska, E. Sobieszczuk‐Nowicka, A. Bagniewska‐Zadworna (2018). Plant Biol J. 10.1111/plb.12672

    2017

  • Effect of auxin and polyamines on protein contents and peroxidase activity during in vitro culture of taro. A.A. Francisco, P.R.R. Ramos, G.P.P. Lima, F. Vianello, S. Kanashiro, A.R. Tavares (2017). Acta Hortic.. 10.17660/actahortic.2017.1155.50
  • Identification of Branched-Chain Polyamines in Hyperthermophiles. Ryota Hidese, Wakao Fukuda, Masaru Niitsu, Shinsuke Fujiwara (2017).10.1007/978-1-4939-7398-9_8
  • Active site geometry of a novel aminopropyltransferase for biosynthesis of hyperthermophile‐specific branched‐chain polyamine. Ryota Hidese, Ka Man Tse, Seigo Kimura, Eiichi Mizohata, Junso Fujita, Yuhei Horai, Naoki Umezawa, Tsunehiko Higuchi, Masaru Niitsu, Tairo Oshima, Tadayuki Imanaka, Tsuyoshi Inoue, Shinsuke Fujiwara (2017). The FEBS Journal. 10.1111/febs.14262
  • Identification of a novel acetylated form of branched-chain polyamine from a hyperthermophilic archaeon Thermococcus kodakarensis. Ryota Hidese, Ki-Hwan Im, Masaki Kobayashi, Masaru Niitsu, Takemitsu Furuchi, Shinsuke Fujiwara (2017).10.1080/09168451.2017.1345616
  • Polyamines in brown rice vinegar function as potent attractants for the spotted wing drosophila. Naoki Akasaka, Haruka Higashikubo, Yuri Ishii, Hisao Sakoda, Shinsuke Fujiwara (2017). Journal of Bioscience and Bioengineering. 10.1016/j.jbiosc.2016.06.014
  • Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications. Dana M. Hardbower, Mohammad Asim, Paula B. Luis, Kshipra Singh, Daniel P. Barry, Chunying Yang, Meredith A. Steeves, John L. Cleveland, Claus Schneider, M. Blanca Piazuelo, Alain P. Gobert, Keith T. Wilson (2017). Proc. Natl. Acad. Sci. U.S.A.. 10.1073/pnas.1614958114
  • Super-Cationic Carbon Quantum Dots Synthesized from Spermidine as an Eye Drop Formulation for Topical Treatment of Bacterial Keratitis. Hong-Jyuan Jian, Ren-Siang Wu, Tzu-Yu Lin, Yu-Jia Li, Han-Jia Lin, Scott G. Harroun, Jui-Yang Lai, Chih-Ching Huang (2017). ACS Nano. 10.1021/acsnano.7b01023
  • Spermidine promotes Bacillus subtilis biofilm formation by activating expression of the matrix regulator slrR. Laura Hobley, Bin Li, Jennifer L. Wood, Sok Ho Kim, Jacinth Naidoo, Ana Sofia Ferreira, Maxim Khomutov, Alexey Khomutov, Nicola R. Stanley-Wall, Anthony J. Michael (2017). Journal of Biological Chemistry. 10.1074/jbc.m117.789644
  • Expression and distribution patterns of spermine, spermidine, and putrescine in rat hair follicle. Yutaro Yamamoto, Takamitsu Makino, Hideo Kudo, Hironobu Ihn, Yasuko Murakami, Senya Matsufuji, Kunio Fujiwara, Masashi Shin (2017). Histochem Cell Biol. 10.1007/s00418-017-1621-1
  • An overview of polyamine metabolism in pancreatic ductal adenocarcinoma. Otto Phanstiel (2017). Intl Journal of Cancer. 10.1002/ijc.31155
  • Investigation of Polyamine Metabolism and Homeostasis in Pancreatic Cancers. Chelsea Massaro, Jenna Thomas, Otto Phanstiel (2017). Medical Sciences. 10.3390/medsci5040032
  • Evaluation of Polyamine Transport Inhibitors in a Drosophila Epithelial Model Suggests the Existence of Multiple Transport Systems. Minpei Wang, Otto Phanstiel, Laurence Von Kalm (2017). Medical Sciences. 10.3390/medsci5040027
  • Spectroscopic and calorimetric characterization of spermine oxidase and its association forms. Alessia Leonetti, Laura Cervoni, Fabio Polticelli, Yuta Kanamori, Zuleyha Nihan Yurtsever, Enzo Agostinelli, Paolo Mariottini, Pasquale Stano, Manuela Cervelli (2017).10.1042/bcj20170744
  • Putrescine catabolism via DAO contributes to proline and GABA accumulation in roots of lupine seedlings growing under salt stress. Jolanta Legocka, Ewa Sobieszczuk-Nowicka, Damian Ludwicki, Teresa Lehmann (2017). Acta Soc Bot Pol. 10.5586/asbp.3549

    2016

  • Ternary Hybrid γ‐Fe2O3/CrVI/Amine Oxidase Nanostructure for Electrochemical Sensing: Application for Polyamine Detection in Tumor Tissue. Emanuela Bonaiuto, Massimiliano Magro, Davide Baratella, Petr Jakubec, Elisabetta Sconcerle, Milo Terzo, Giovanni Miotto, Alberto Macone, Enzo Agostinelli, Silvano Fasolato, Rina Venerando, Gabriella Salviulo, Ondrej Malina, Radek Zboril, Fabio Vianello (2016). Chemistry A European J. 10.1002/chem.201600156
  • Naturally occurring branched-chain polyamines induce a crosslinked meshwork structure in a giant DNA. Akira Muramatsu, Yuta Shimizu, Yuko Yoshikawa, Wakao Fukuda, Naoki Umezawa, Yuhei Horai, Tsunehiko Higuchi, Shinsuke Fujiwara, Tadayuki Imanaka, Kenichi Yoshikawa (2016).10.1063/1.4972066
  • Spermine cycling in mitochondria is mediated by adenine nucleotide translocase activity: mechanism and pathophysiological implications. Silvia Grancara, Lisa Dalla Via, Aida Nelly García-Argáez, Shinji Ohkubo, Elena Pacella, Sabrina Manente, Marcantonio Bragadin, Antonio Toninello, Enzo Agostinelli (2016). Amino Acids. 10.1007/s00726-016-2264-6
  • Epigenetic silencing of miR-124 prevents spermine oxidase regulation: implications for Helicobacter pylori-induced gastric cancer. T Murray-Stewart, J C Sierra, M B Piazuelo, R M Mera, R Chaturvedi, L E Bravo, P Correa, B G Schneider, K T Wilson, R A Casero (2016). Oncogene. 10.1038/onc.2016.91
  • Synthesis of Self‐Assembled Spermidine‐Carbon Quantum Dots Effective against Multidrug‐Resistant Bacteria. Yu‐Jia Li, Scott G. Harroun, Yu‐Chia Su, Chun‐Fang Huang, Binesh Unnikrishnan, Han‐Jia Lin, Chia‐Hua Lin, Chih‐Ching Huang (2016). Adv Healthcare Materials. 10.1002/adhm.201600297
  • A suggested vital function for eIF‐5A and dhs genes during murine malaria blood‐stage infection. David Kersting, Mirko Krüger, Julia M. Sattler, Ann‐Kristin Mueller, Annette Kaiser (2016). FEBS Open Bio. 10.1002/2211-5463.12093
  • Novel hydroxylamine-containing analogues of 1-guanidino-7-aminoheptane (GC7), an effective inhibitor of deoxyhypusine synthase. M. A. Khomutov, A. R. Simonian, J. Weisell, J. Vepsalainen, S. N. Kochetkov, A. R. Khomutov (2016). Russ J Bioorg Chem. 10.1134/s1068162016040099
  • Synthesis of 2,11-bis(methylidene)spermine, a new inhibitor of spermine oxidase. N. A. Grigorenko, M. A. Khomutov, A. R. Simonian, S. N. Kochetkov, A. R. Khomutov (2016). Russ J Bioorg Chem. 10.1134/s1068162016030080
  • Triethylenetetramine modulates polyamine and energy metabolism and inhibits cancer cell proliferation. Mervi T. Hyvönen, Sebahat Ucal, Markku Pasanen, Sirpa Peräniemi, Janne Weisell, Maxim Khomutov, Alex R. Khomutov, Jouko Vepsäläinen, Leena Alhonen, Tuomo A. Keinänen (2016).10.1042/bcj20160134
  • Two stems with different characteristics and an internal loop in an RNA aptamer contribute to spermine-binding. Akihiro Oguro, Asumi Yanagida, Yuta Fujieda, Ryo Amano, Maina Otsu, Taiichi Sakamoto, Gota Kawai, Senya Matsufuji (2016). J Biochem. 10.1093/jb/mvw062
  • Polyamine Antagonist Therapies Inhibit Neuroblastoma Initiation and Progression. Nicholas F. Evageliou, Michelle Haber, Annette Vu, Theodore W. Laetsch, Jayne Murray, Laura D. Gamble, Ngan Ching Cheng, Kangning Liu, Megan Reese, Kelly A. Corrigan, David S. Ziegler, Hannah Webber, Candice S. Hayes, Bruce Pawel, Glenn M. Marshall, Huaqing Zhao, Susan K. Gilmour, Murray D. Norris, Michael D. Hogarty (2016).10.1158/1078-0432.ccr-15-2539
  • Polyamines and transglutaminases: future perspectives. Enzo Agostinelli (2016). Amino Acids. 10.1007/s00726-016-2326-9
  • Ser/Thr kinases and polyamines in the regulation of non-canonical functions of elongation factor 1A. Nunzia Migliaccio, Nicola M. Martucci, Immacolata Ruggiero, Carmen Sanges, Shinji Ohkubo, Annalisa Lamberti, Enzo Agostinelli, Paolo Arcari (2016). Amino Acids. 10.1007/s00726-016-2311-3
  • Stability of spermine oxidase to thermal and chemical denaturation: comparison with bovine serum amine oxidase. Manuela Cervelli, Alessia Leonetti, Laura Cervoni, Shinji Ohkubo, Marla Xhani, Pasquale Stano, Rodolfo Federico, Fabio Polticelli, Paolo Mariottini, Enzo Agostinelli (2016). Amino Acids. 10.1007/s00726-016-2273-5

    2015

  • Polyamines in conventional and organic vegetables exposed to exogenous ethylene. Maria Rosecler Miranda Rossetto, Fabio Vianello, Margarida Juri Saeki, Giuseppina Pace Pereira Lima (2015). Food Chemistry. 10.1016/j.foodchem.2015.04.125
  • A novel enzyme with spermine oxidase properties in bovine liver mitochondria: Identification and kinetic characterization. Emanuela Bonaiuto, Silvia Grancara, Pamela Martinis, Annarita Stringaro, Marisa Colone, Enzo Agostinelli, Alberto Macone, Roberto Stevanato, Fabio Vianello, Antonio Toninello, Maria Luisa Di Paolo (2015). Free Radical Biology and Medicine. 10.1016/j.freeradbiomed.2015.01.001
  • Pathophysiological implications of mitochondrial oxidative stress mediated by mitochondriotropic agents and polyamines: the role of tyrosine phosphorylation. Silvia Grancara, Francesca Zonta, Shinji Ohkubo, Anna Maria Brunati, Enzo Agostinelli, Antonio Toninello (2015). Amino Acids. 10.1007/s00726-015-1964-7
  • The Essential Role of Spermidine in Growth of Agrobacterium tumefaciens Is Determined by the 1,3-Diaminopropane Moiety. Sok Ho Kim, Yi Wang, Maxim Khomutov, Alexey Khomutov, Clay Fuqua, Anthony J. Michael (2015). ACS Chem. Biol.. 10.1021/acschembio.5b00893
  • Enantioselective synthesis of (R)- and (S)-3-methylspermidines. M. A. Khomutov, T. A. Keinanen, M. T. Hyvonen, J. Weisell, J. Vepsalainen, L. Alhonen, S. N. Kochetkov, A. R. Khomutov (2015). Russ J Bioorg Chem. 10.1134/s1068162015050064
  • Enantiomers of 3-Methylspermidine Selectively Modulate Deoxyhypusine Synthesis and Reveal Important Determinants for Spermidine Transport. Mervi T. Hyvönen, Maxim Khomutov, Marine Petit, Janne Weisell, Sergey N. Kochetkov, Leena Alhonen, Jouko Vepsäläinen, Alex R. Khomutov, Tuomo A. Keinänen (2015). ACS Chem. Biol.. 10.1021/cb500938e
  • Inhibition of Polyamine Uptake Potentiates the Anti‐Proliferative Effect of Polyamine Synthesis Inhibition and Preserves the Contractile Phenotype of Vascular Smooth Muscle Cells. Mario Grossi, Otto Phanstiel, Catarina Rippe, Karl Swärd, Azra Alajbegovic, Sebastian Albinsson, Amalia Forte, Lo Persson, Per Hellstrand, Bengt‐Olof Nilsson (2015). Journal Cellular Physiology. 10.1002/jcp.25236
  • Bioconjugation of gold-polymer core–shell nanoparticles with bovine serum amine oxidase for biomedical applications. I. Venditti, T.F. Hassanein, I. Fratoddi, L. Fontana, C. Battocchio, F. Rinaldi, M. Carafa, C. Marianecci, M. Diociaiuti, E. Agostinelli, C. Cametti, M.V. Russo (2015). Colloids and Surfaces B: Biointerfaces. 10.1016/j.colsurfb.2015.06.052
  • Lead-stress induced changes in the content of free, thylakoid- and chromatin-bound polyamines, photosynthetic parameters and ultrastructure in greening barley leaves. Jolanta Legocka, Ewa Sobieszczuk-Nowicka, Łukasz Wojtyla, Sławomir Samardakiewicz (2015). Journal of Plant Physiology. 10.1016/j.jplph.2015.07.010

    2014

  • Nanoparticle strategies for cancer therapeutics: Nucleic acids, polyamines, bovine serum amine oxidase and iron oxide nanoparticles (Review). ENZO AGOSTINELLI, FABIO VIANELLO, GIUSEPPE MAGLIULO, THRESIA THOMAS, T.J. THOMAS (2014).10.3892/ijo.2014.2706
  • Long-Chain and Branched Polyamines in Thermophilic Microbes. Wakao Fukuda, Ryota Hidese, Shinsuke Fujiwara (2014).10.1007/978-4-431-55212-3_2
  • Protein Synthesis and Polyamines in Thermophiles: Effect of Polyamines on Nucleic Acid Maintenance and Gene Expression. Shinsuke Fujiwara, Ryota Hidese, Takahiro Inoue, Wakao Fukuda (2014).10.1007/978-4-431-55212-3_12
  • Identification of a Novel Aminopropyltransferase Involved in the Synthesis of Branched-Chain Polyamines in Hyperthermophiles. Kazuma Okada, Ryota Hidese, Wakao Fukuda, Masaru Niitsu, Koichi Takao, Yuhei Horai, Naoki Umezawa, Tsunehiko Higuchi, Tairo Oshima, Yuko Yoshikawa, Tadayuki Imanaka, Shinsuke Fujiwara (2014). J Bacteriol. 10.1128/jb.01515-14
  • Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase. R Chaturvedi, T de Sablet, M Asim, M B Piazuelo, D P Barry, T G Verriere, J C Sierra, D M Hardbower, A G Delgado, B G Schneider, D A Israel, J Romero-Gallo, T A Nagy, D R Morgan, T Murray-Stewart, L E Bravo, R M Peek, J G Fox, P M Woster, R A Casero, P Correa, K T Wilson (2014). Oncogene. 10.1038/onc.2014.273
  • Polyamine-Blocking Therapy Reverses Immunosuppression in the Tumor Microenvironment. Candace S. Hayes, Allyson C. Shicora, Martin P. Keough, Adam E. Snook, Mark R. Burns, Susan K. Gilmour (2014).10.1158/2326-6066.cir-13-0120-t
  • The combined treatment with chloroquine and the enzymatic oxidation products of spermine overcomes multidrug resistance of melanoma M14 ADR2 cells: A new therapeutic approach. ENZO AGOSTINELLI, MARIA CONDELLO, GIAMPIERO TEMPERA, ALBERTO MACONE, GIUSEPPINA BOZZUTO, SHINJI OHKUBO, ANNARICA CALCABRINI, GIUSEPPE ARANCIA, AGNESE MOLINARI (2014).10.3892/ijo.2014.2502
  • Polyamines and transglutaminases: biological, clinical, and biotechnological perspectives. Enzo Agostinelli (2014). Amino Acids. 10.1007/s00726-014-1688-0
  • Polyamines are common players in different facets of plant programmed cell death. G. Cai, E. Sobieszczuk-Nowicka, I. Aloisi, L. Fattorini, D. Serafini-Fracassini, S. Del Duca (2014). Amino Acids. 10.1007/s00726-014-1865-1

    2013

  • Bidirectional fluxes of spermine across the mitochondrial membrane. Silvia Grancara, Pamela Martinis, Sabrina Manente, Aida Nelly García-Argáez, Giampiero Tempera, Marcantonio Bragadin, Lisa Dalla Via, Enzo Agostinelli, Antonio Toninello (2013). Amino Acids. 10.1007/s00726-013-1591-0
  • Commentary on: Hairless and the polyamine putrescine form a negative regulatory loop in the epidermis. Yuval Ramot, Leah A. Vardy (2013). Experimental Dermatology. 10.1111/exd.12244
  • Spermine oxidase is a regulator of macrophage host response to Helicobacter pylori: enhancement of antimicrobial nitric oxide generation by depletion of spermine. Rupesh Chaturvedi, Mohammad Asim, Daniel P. Barry, Jeanetta W. Frye, Robert A. Casero, Keith T. Wilson (2013). Amino Acids. 10.1007/s00726-013-1531-z
  • Duplication and Diversification of the Spermidine/Spermine N1-acetyltransferase 1 Genes in Zebrafish. Yi-Chin Lien, Ting-Yu Ou, Yu-Tzu Lin, Po-Chih Kuo, Han-Jia Lin (2013). PLoS ONE. 10.1371/journal.pone.0054017
  • Hydroxylamine derivatives for regulation of spermine and spermidine metabolism. M. A. Khomutov, J. Weisell, M. Hyvönen, T. A. Keinänen, J. Vepsäläinen, L. Alhonen, A. R. Khomutov, S. N. Kochetkov (2013). Biochemistry Moscow. 10.1134/s0006297913130051
  • Multiple forms of mouse antizyme inhibitor 1 mRNA differentially regulated by polyamines. Yasuko Murakami, Makiko Ohkido, Hiroko Takizawa, Noriyuki Murai, Senya Matsufuji (2013). Amino Acids. 10.1007/s00726-013-1598-6
  • Putrescine Importer PlaP Contributes to Swarming Motility and Urothelial Cell Invasion in Proteus mirabilis. Shin Kurihara(栗原新), Yumi Sakai(坂井友美), Hideyuki Suzuki(鈴木秀之), Aaron Muth, Otto Phanstiel, Philip N. Rather (2013). Journal of Biological Chemistry. 10.1074/jbc.m113.454090
  • Innovative approaches to the use of polyamines for DNA nanoparticle preparation for gene therapy. Veena Vijayanathan, Enzo Agostinelli, Thresia Thomas, T. J. Thomas (2013). Amino Acids. 10.1007/s00726-013-1549-2
  • Spermine metabolism and radiation-derived reactive oxygen species for future therapeutic implications in cancer: an additive or adaptive response. Roberto Amendola, Manuela Cervelli, Giampiero Tempera, Emiliano Fratini, Luigi Varesio, Paolo Mariottini, Enzo Agostinelli (2013). Amino Acids. 10.1007/s00726-013-1579-9
  • Reactive oxygen species spermine metabolites generated from amine oxidases and radiation represent a therapeutic gain in cancer treatments. ROBERTO AMENDOLA, MANUELA CERVELLI, EMILIANO FRATINI, DAVIDE E. SALLUSTIO, GIAMPIERO TEMPERA, TAICHI UESHIMA, PAOLO MARIOTTINI, ENZO AGOSTINELLI (2013).10.3892/ijo.2013.2013
  • MDL 72527 and spermine oxidation products induce a lysosomotropic effect and mitochondrial alterations in tumour cells. Enzo Agostinelli, Giampiero Tempera, Laura Dalla Vedova, Maria Condello, Giuseppe Arancia (2013).10.1042/bst0411773u
  • Novel polyamine analogues: From substrates towards potential inhibitors of monoamine oxidases. Emanuela Bonaiuto, Andrea Milelli, Giorgio Cozza, Vincenzo Tumiatti, Chiara Marchetti, Enzo Agostinelli, Carmela Fimognari, Patrizia Hrelia, Anna Minarini, Maria Luisa Di Paolo (2013). European Journal of Medicinal Chemistry. 10.1016/j.ejmech.2013.07.005
  • Plastid‐associated polyamines: their role in differentiation, structure, functioning, stress response and senescence. E. Sobieszczuk‐Nowicka, J. Legocka (2013). Plant Biol J. 10.1111/plb.12058

    2012

  • Catalytically active bovine serum amine oxidase bound to fluorescent and magnetically drivable nanoparticles. Fabio Vianello, Sinigaglia, Magro, Miotto, Cardillo, Agostinelli, Zboril, Bidollari (2012). IJN. 10.2147/ijn.s28237
  • Erratum to: Preliminary kinetic characterization of a copper amine oxidase from rat liver mitochondria matrix. Roberto Stevanato, Sara Cardillo, Michele Braga, Angela De Iuliis, Valentina Battaglia, Antonio Toninello, Enzo Agostinelli, Fabio Vianello (2012). Amino Acids. 10.1007/s00726-012-1227-9
  • AMD1 is essential for ESC self-renewal and is translationally down-regulated on differentiation to neural precursor cells. Dawei Zhang, Tianyun Zhao, Haw Siang Ang, Peini Chong, Ryotaro Saiki, Kazuei Igarashi, Henry Yang, Leah A. Vardy (2012). Genes Dev.. 10.1101/gad.182998.111
  • Editorial: Orchestration of macrophage polarization by polyamines. Alain P Gobert, Keith T Wilson (2012).10.1189/jlb.0112047
  • L-arginine uptake by cationic amino acid transporter 2 is essential for colonic epithelial cell restitution. Kshipra Singh, Lori A. Coburn, Daniel P. Barry, Jean-Luc Boucher, Rupesh Chaturvedi, Keith T. Wilson (2012). American Journal of Physiology-Gastrointestinal and Liver Physiology. 10.1152/ajpgi.00544.2011
  • Spermine oxidase, a polyamine catabolic enzyme that linksHelicobacter pyloriCagA and gastric cancer risk. Rupesh Chaturvedi, Thibaut de Sablet, Richard M. Peek, Keith T. Wilson (2012). Gut Microbes. 10.4161/gmic.19345
  • In vitro and in vivo silencing of plasmodial dhs and eIf-5a genes in a putative, non-canonical RNAi-related pathway. Andreas Schwentke, Marcel Krepstakies, Ann-Kristin Mueller, Christiane Hammerschmidt-Kamper, Basma A Motaal, Tina Bernhard, Joachim Hauber, Annette Kaiser (2012). BMC Microbiol. 10.1186/1471-2180-12-107
  • Biogenic polyamines spermine and spermidine activate RNA polymerase and inhibit RNA helicase of hepatitis C virus. A. N. Korovina, V. L. Tunitskaya, M. A. Khomutov, A. R. Simonian, A. R. Khomutov, A. V. Ivanov, S. N. Kochetkov (2012). Biochemistry Moscow. 10.1134/s0006297912100094
  • Spermine Oxidation Products Induce Mitochondrial Alterations on Tumor Cells. Enzo Agostinelli (2012).10.2478/v10283-012-0015-5
  • Erratum to: Chronic exposure to agmatine results in the selection of agmatine-resistant hepatoma cells. Andrea Bandino, Valentina Battaglia, Vittoria Bravoco, Chiara Busletta, Alessandra Compagnone, Carlo Cravanzola, Floriana Meli, Enzo Agostinelli, Maurizio Parola, Sebastiano Colombatto (2012). Amino Acids. 10.1007/s00726-012-1241-y

    2011

  • Do mammalian amine oxidases and the mitochondrial polyamine transporter have similar protein structures?. Enzo Agostinelli, Antonio Toninello, Fabio Vianello, Roberto Stevanato (2011). Amino Acids. 10.1007/s00726-011-0988-x
  • The structure of maize polyamine oxidase K300M mutant in complex with the natural substrates provides a snapshot of the catalytic mechanism of polyamine oxidation. Annarita Fiorillo, Rodolfo Federico, Fabio Polticelli, Alberto Boffi, Franco Mazzei, Massimo Di Fusco, Andrea Ilari, Paraskevi Tavladoraki (2011). The FEBS Journal. 10.1111/j.1742-4658.2010.08000.x
  • Further characterization of agmatine binding to mitochondrial membranes: involvement of imidazoline I2 receptor. Pamela Martinis, Valentina Battaglia, Silvia Grancara, Lisa Dalla Via, Vito Di Noto, Stefania Saccoccio, Enzo Agostinelli, Marcantonio Bragadin, Maria Angelica Grillo, Antonio Toninello (2011). Amino Acids. 10.1007/s00726-011-0992-1
  • Effect of peroxides on spermine transport in rat brain and liver mitochondria. Valentina Battaglia, Elena Tibaldi, Silvia Grancara, Francesca Zonta, Anna Maria Brunati, Pamela Martinis, Marcantonio Bragadin, Maria Angelica Grillo, Giampiero Tempera, Enzo Agostinelli, Antonio Toninello (2011). Amino Acids. 10.1007/s00726-011-0990-3
  • Arginine and polyamines in Helicobacter pylori-induced immune dysregulation and gastric carcinogenesis. Rupesh Chaturvedi, Thibaut de Sablet, Lori A. Coburn, Alain P. Gobert, Keith T. Wilson (2011). Amino Acids. 10.1007/s00726-011-1038-4
  • Spermine Oxidase Mediates the Gastric Cancer Risk Associated With Helicobacter pylori CagA. Rupesh Chaturvedi, Mohammad Asim, Judith Romero–Gallo, Daniel P. Barry, Svea Hoge, Thibaut de Sablet, Alberto G. Delgado, Lydia E. Wroblewski, M. Blanca Piazuelo, Fang Yan, Dawn A. Israel, Robert A. Casero, Pelayo Correa, Alain P. Gobert, D. Brent Polk, Richard M. Peek, Keith T. Wilson (2011). Gastroenterology. 10.1053/j.gastro.2011.07.045
  • Translational control of eIF5A in various diseases. Annette Kaiser (2011). Amino Acids. 10.1007/s00726-011-1042-8
  • Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A. Mervi T. Hyvönen, Tuomo A. Keinänen, Maxim Khomutov, Alina Simonian, Jouko Vepsäläinen, Jong Hwan Park, Alex R. Khomutov, Leena Alhonen, Myung Hee Park (2011). Amino Acids. 10.1007/s00726-011-0984-1
  • Leishmania donovani: Structural insignt in the recognition of C-methylated analogues of spermidine as natural polyamines. S. Mandal, M. A. Khomutov, A. R. Simonian, S. N. Kochetkov, R. Madhubala (2011). Mol Biol. 10.1134/s002689331104008x
  • The Use of Novel C-Methylated Spermidine Derivatives To Investigate the Regulation of Polyamine Metabolism. Mervi T. Hyvönen, Tuomo A. Keinänen, Maxim Khomutov, Alina Simonian, Janne Weisell, Sergey N. Kochetkov, Jouko Vepsäläinen, Leena Alhonen, Alex R. Khomutov (2011). J. Med. Chem.. 10.1021/jm200293r
  • Novel metabolically stable and functionally active mimetic of spermidine. M. A. Khomutov, M. T. Hyvönen, A. R. Simonian, J. Vepsäläinen, L. Alhonen, S. N. Kochetkov, T. A. Keinänen (2011). Russ J Bioorg Chem. 10.1134/s1068162011020075
  • Methylated Polyamines as Research Tools. Alex R. Khomutov, Janne Weisell, Maxim A. Khomutov, Nikolay A. Grigorenko, Alina R. Simonian, Merja R. Häkkinen, Tuomo A. Keinänen, Mervi T. Hyvönen, Leena Alhonen, Sergey N. Kochetkov, Jouko Vepsäläinen (2011).10.1007/978-1-61779-034-8_29
  • Defining the role of polyamines in colon carcinogenesis using mouse models. NataliaA Ignatenko, EugeneW Gerner, DavidG Besselsen (2011). J Carcinog. 10.4103/1477-3163.79673
  • Polyamines in cancer. Edwin A. Paz, Jenaro Garcia-Huidobro, Natalia A. Ignatenko (2011).10.1016/b978-0-12-387025-4.00002-9
  • A prolonged and exaggerated wound response with elevated ODC activity mimics early tumor development. Candace S. Hayes, Karen DeFeo, Hong Dang, Carol S. Trempus, Rebecca J. Morris, Susan K. Gilmour (2011).10.1093/carcin/bgr129
  • Role of polyamines, their analogs and transglutaminases in biological and clinical perspectives. Enzo Agostinelli (2011). Amino Acids. 10.1007/s00726-011-1129-2
  • Novel Reversible Monoamine Oxidase A Inhibitors: Highly Potent and Selective 3-(1H-Pyrrol-3-yl)-2-oxazolidinones. Sergio Valente, Stefano Tomassi, Giampiero Tempera, Stefania Saccoccio, Enzo Agostinelli, Antonello Mai (2011). J. Med. Chem.. 10.1021/jm201011x

    2010

  • Preliminary kinetic characterization of a copper amine oxidase from rat liver mitochondria matrix. Roberto Stevanato, Sara Cardillo, Michele Braga, Angela De Iuliis, Valentina Battaglia, Antonio Toninello, Enzo Agostinelli, Fabio Vianello (2010). Amino Acids. 10.1007/s00726-010-0708-y
  • Dual Biosynthesis Pathway for Longer-Chain Polyamines in the Hyperthermophilic Archaeon
    Thermococcus kodakarensis
    . Nanako Morimoto, Wakao Fukuda, Nanami Nakajima, Takeaki Masuda, Yusuke Terui, Tamotsu Kanai, Tairo Oshima, Tadayuki Imanaka, Shinsuke Fujiwara (2010). J Bacteriol. 10.1128/jb.00279-10
  • Increased expression and cellular localization of spermine oxidase in ulcerative colitis and relationship to disease activity. Shih-Kuang S. Hong, Rupesh Chaturvedi, Blanca M. Piazuelo, Lori A. Coburn, Christopher S. Williams, Alberto G. Delgado, Robert A. Casero, David A. Schwartz, Keith T. Wilson (2010). Inflammatory Bowel Diseases. 10.1002/ibd.21224
  • Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production. Rupesh Chaturvedi, Mohammad Asim, Svea Hoge, Nuruddeen D. Lewis, Kshipra Singh, Daniel P. Barry, Thibaut de Sablet, M. Blanca Piazuelo, Aditya R. Sarvaria, Yulan Cheng, Ellen I. Closs, Robert A. Casero, Alain P. Gobert, Keith T. Wilson (2010). Gastroenterology. 10.1053/j.gastro.2010.06.060
  • A high-throughput colorimetric assay to characterize the enzyme kinetic and cellular activity of spermidine/spermine N1-acetyltransferase 1. Han-Jia Lin, Yi-Chin Lien, Chun-Hua Hsu (2010). Analytical Biochemistry. 10.1016/j.ab.2010.07.036